130108-73-5

Usage

InChI:InChI=1/C10H12N8O3/c11-8-7-9(14-3-13-8)18(4-15-7)6-1-5(20)10(2-19,21-6)16-17-12/h3-6,19-20H,1-2H2,(H2,11,13,14)/t5-,6+,10+/m0/s1

Upstream product

• 140226-25-1 4'-azido-2',5'-dideoxy-5'-iodo-N⁶,N⁶,O^3'-tribenzoyladenosine 
• 958-09-8 2'-deoxy-D-adenosine 
• 140226-23-9 4'-azido-2',5'-dideoxy-5'-iodoadenosine 
• 140226-18-2 2',5'-dideoxy-5'-iodoadenosine 
• 59676-20-9 9-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)adenine 

Relevant academic research and scientific papers

Antiviral agents

Nucleoside compounds of the formula STR1 wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ester, provided that Y is H; or Z is STR2 where n is zero, one, two or three; and Z' is N3 or OCH3 ; provided that when X' and Y' are OH and Z' is N3, B is not cytosine, and when X' and Y' are OH and Z' is OCH3, B is not uracil, adenine or cytosine; and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

A series of nucleosides were synthesized in which the 4'-hydrogen was substituted with either an azido or a methoxy group. The key steps in the syntheses of the 4'-azido analogues were the stereo- and regioselective addition of iodine azide to a 4'-unsatu