130111-08-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(BENZYLOXY)-2-HYDROXYPROPANOIC ACID is used as a reactant for the synthetic preparation of 2-Oxopiperazine derivatives, which are important in the development of pharmaceutical compounds. The application reason is that these derivatives have shown potential in various therapeutic areas, including the treatment of central nervous system disorders, cardiovascular diseases, and certain types of cancer.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-(BENZYLOXY)-2-HYDROXYPROPANOIC ACID serves as a versatile building block for the creation of more complex molecules. The application reason is its unique structural features, which allow for further functionalization and the formation of a wide range of compounds with diverse properties and potential applications.
Used in Research and Development:
3-(BENZYLOXY)-2-HYDROXYPROPANOIC ACID is also used as a research compound in academic and industrial laboratories. The application reason is to explore its chemical properties, reactivity, and potential applications in various fields, such as materials science, pharmaceuticals, and agrochemicals.

Upstream product

• 23392-30-5 methyl 6-O-benzyl-α-D-galactopyranoside 
• 10433-52-0 O-benzyl-D-serine 
• 4726-96-9 O-Benzyl-L-serine 
• 68761-98-8 H-Ser(OBn)-OH trifluoroacetate 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 100-44-7 benzyl chloride 

Downstream Products

• 209907-54-0 methyl (2R)-3-benzyloxy-2-hydroxypropanoate 
• 1448013-34-0 2-N-acetyl-6-O-allyl-3,4-di-O-benzyl-α-D-glucosaminopyranosyl-(1→3)-2-N-acetyl-4-O-benzyl-6-O-levulinoyl-α-D-glucosaminopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-23-7 2-N-acetyl-3,4-di-O-benzyl-6-O-prop-1-en-α-D-glucosaminopyranosyl-(1→3)-2-N-acetyl-4-O-benzyl-α-D-glucosaminopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-36-2 2-N-acetyl-3,4-di-O-benzyl-α-D-glucosaminopyranosyl-(1→3)-2-N-acetyl-4-O-benzyl-α-D-glucosaminopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-24-8 2-N-acetyl-3,4-di-O-benzyl-6-O-prop-1-en-α-D-glucosaminopyranosyl-(1→3)-2-N-acetyl-4-O-benzyl-6-((N,N,-diisopropylamino)-2-cyanoethylphosphite)-α-D-glucosaminopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-31-7 2-azido-4-O-benzyl-2-deoxy-6-O-levulinoyl-3-O-(2-naphthalenylmethyl)-α-D-glucopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-32-8 2-azido-4-O-benzyl-2-deoxy-6-O-levulinoyl-α-D-glucopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 1448013-33-9 6-O-allyl-2-azido-3,4-di-O-benzyl-2-deoxy-α-D-glucopyranosyl-(1→3)-2-azido-4-O-benzyl-2-deoxy-6-O-levulinoyl-α-D-glucopyranosyl-(1→2)-benzyl (2R)-3-benzyloxypropanoate 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 23214-66-6 (R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 2930-05-4 (S)-benzyl glycidyl ether 
• 127744-29-0 (S)-1-benzyloxy-3-(tert-butyldimethylsilanyloxy)propan-2-ol 
• 127744-30-3 methyl-(2R)-3-benzyloxy-2-benzoyloxy-propanoate 

Relevant academic research and scientific papers

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

There is an urgent need for novel therapeutic approaches to treat Alzheimer's disease (AD) with the ability to both alleviate the clinical symptoms and halt the progression of the disease. AD is characterized by the accumulation of amyloid-β (Aβ) peptides

PROTEIN TYROSINE PHOSPHATASE DEGRADERS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.

Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer

The first total synthesis of vioprolide D was accomplished in an overall yield of 2.0 % starting from methyl (2S)-3-benzyloxy-2-hydroxypropanoate (16 steps in the longest linear sequence). The cyclic depsipeptide was assembled from two building blocks of

Synthesis of carbohydrate-grafted glycopolymers using a catalyst-free, perfluoroarylazide-mediated fast staudinger reaction

Glycopolymers have gained increasing importance in investigating glycan-lectin interactions, as drug delivery vehicles and in modulating interactions with proteins. The synthesis of these glycopolymers is still a challenging and rigorous exercise. In this

JAK1 SELECTIVE INHIBITORS

Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS

The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).

Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.

Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.

Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine

Clostridium difficile is a leading cause of severe nosocomial infections. Cell-surface carbohydrate antigens are promising vaccine candidates. Here we report the first total synthesis of oligomers of the lipoteichoic acid antigen repeating unit. Synthetic glycan microarrays revealed anti-glycan antibodies in the blood of patients that help to define epitopes for vaccine development.

Continuous multiple liquid-liquid separation: Diazotization of amino acids in flow

A second-generation laboratory-scale, modular liquid-liquid separation device based on computer-controlled high-pressure pumps and a high-resolution digital camera has been invented. The diazotization of amino acids to produce valuable chiral hydroxyacids is demonstrated in flow for the first time. The use of a triple-separator system in conjuction with the developed diazotization process allows the safe and efficient production and automated isolation of multigram quantities of valuable chiral hydroxyacids.