130111-52-3Relevant academic research and scientific papers
PREPARATION OF ALKYL-SUBSTITUTED INDOLES IN THE BENZENE PORTION. Part 4
Muratake, Hideaki,Natsume, Mitsutaka
, p. 691 - 700 (2007/10/02)
A useful method for the preparation of variously substituted polyalkylindoles (3b) was established by H2SO4-catalyzed cyclization reaction of 1b, where the substituent Y was designated as either the hydroxy or alkoxy group, to yield 3a in good yields.The substrate (1b) was prepared from 1-phenylsulfonylpyrrole (5) by way of 1-phenylsulfonyl-2-pyrrolyl derivatives (4), e.g., 6 and 13, followed by the aldol reaction for the elongation of their carbonyl functions.
