1301235-30-2

Upstream product

• 1350556-07-8 methyl 2-benzyloxycarbonylamino-2-deoxy-3-O-methoxycarbonyl-α-D-glucopyranoside 
• 1350556-10-3 methyl 2-benzyloxycarbonylamino-2-deoxy-4-O-mesyl-3-O-methoxycarbonyl-α-D-glucopyranoside 
• 1350556-11-4 methyl 2-benzyloxycarbonylamino-2-deoxy-3-O-methoxycarbonyl-6-O-tert-butyldimethylsilyl-α-D-glucopyranoside 
• 1350556-13-6 methyl 2-benzyloxycarbonylamino-2-deoxy-4-O-mesyl-3-O-methoxycarbonyl-6-O-tert-butyldimethylsilyl-α-D-glucopyranoside 
• 1350556-15-8 methyl 6-formyl-2-benzyloxycarbonylamino-2-deoxy-3-O-methoxycarbonyl-α-D-glucopyranoside 
• 1350556-18-1 methyl 2-benzyloxycarbonylamino-4,5-dehydro-2,4-dideoxy-3-O-methoxycarbonyl-α-D-glucopyranoside 
• 1350556-20-5 methyl 2-benzyloxycarbonylamino-4,5-dehydro-2,4-dideoxy-3-O-methoxycarbonyl-6-O-tert-butyldimethylsilyl-α-D-glucopyranoside 
• 1350556-22-7 methyl 2-benzyloxycarbonylamino-3,4-dehydro-2,3,4-trideoxy-6-O-tert-butyldimethylsilyl-α-D-glucopyranoside 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 60076-41-7 methyl 4,6-O-benzylidene-2-(benzyloxycarbonyl)amino-2-deoxy-α-D-glucopyranoside 
• 4704-15-8 ((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Hybrid aminoglycoside antibiotics via tsuji palladium-catalyzed allylic deoxygenation

Biosynthetically inspired manipulation of the antibiotic paromomycin led, in six high-yielding steps, to a ring A harboring an R,β-unsaturated 6′- aldehyde and an allylic 3′-methylcarbonate group. Tsuji deoxygenation in the presence of 5 mol % Pd2(dba)3 and Bu3P granted access to a novel series of 3′,4′-dideoxy- 4′,5′-dehydro ring A hybrids. The neomycin-sisomicin hybrid exhibited superior in vitro antibacterial activity to the parent compound neomycin.