1350556-10-3Relevant articles and documents
Hybrid aminoglycoside antibiotics via tsuji palladium-catalyzed allylic deoxygenation
Hanessian, Stephen,Maianti, Juan Pablo,Matias, Rowena D.,Feeney, Lee Ann,Armstrong, Eliana S.
, p. 6476 - 6479 (2012/02/14)
Biosynthetically inspired manipulation of the antibiotic paromomycin led, in six high-yielding steps, to a ring A harboring an R,β-unsaturated 6′- aldehyde and an allylic 3′-methylcarbonate group. Tsuji deoxygenation in the presence of 5 mol % Pd2(dba)3 and Bu3P granted access to a novel series of 3′,4′-dideoxy- 4′,5′-dehydro ring A hybrids. The neomycin-sisomicin hybrid exhibited superior in vitro antibacterial activity to the parent compound neomycin.