130127-81-0

Upstream product

• 10353-53-4 1,2-epoxy-5-hexene 
• 591-50-4 iodobenzene 
• 18328-11-5 3-benzyl propionaldehyde 
• 55283-02-8 methyl (E)-6-phenyl-2-hexenoate 
• 1823-14-9 5-phenyl-1-pentyne 
• 84299-17-2 ethyl (E)-6-phenylhex-2-enoate 
• 77877-57-7 6-phenyl-2-hexyn-1-ol 

Downstream Products

• 1266551-67-0 (E)-1-(trimethylsilyl)-6-phenylhex-2-en-1-ol 
• 1266551-62-5 (E)-triisopropyl((6-phenylhex-2-en-1-yl)oxy)silane 
• 1266551-45-4 (E)-1-(triisopropylsilyl)-6-phenylhex-2-enyl 4-nitrobenzoate 
• 1266551-49-8 (E)-1-(triisopropylsilyl)-6-phenylhex-1-en-3-yl 4-nitrobenzoate 
• 1266551-85-2 (E)-1-(triiospropylsilyl)-6-phenylhex-1-en-3-ol 
• 1266551-87-4 (E)-1-(triisopropylsilyl)-6-phenylhex-2-enyl 4-nitrobenzoate 
• 1266551-89-6 dimethyl(phenyl)((1E,3E/Z)-6-phenylhexa-1,3-dienyl)silane 
• 1266551-46-5 C₂₇H₂₉NO₄Si 
• 1266551-50-1 C₂₇H₂₉NO₄Si 
• 1266551-91-0 (R,E)-1-(dimethyl(phenyl)lsilyl)-6-phenylhex-1-en-3-ol 
• 1266551-92-1 (E)-1-(dimethyl(phenyl)silyl)-6-phenylhex-2-enyl-4-nitrobenzoate 
• 1266551-94-3 trimethyl((1E,3E/Z)-6-phenylhexa-1,3-dienyl)silane 

Relevant academic research and scientific papers

Stereoselective Carbocyclization of Vinyloxiranes Catalyzed by Lewis Acids: Construction of the Musellarin Tricyclic Core

Stereoselective carbocyclizations of vinyloxiranes were efficiently catalyzed by Lewis acids to provide cyclic homoallyl alcohols as single isomers. The choice of Lewis acid, B(C6F5)3 was crucial for the stereoselective tr

Ligand-controlled cobalt-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes

The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.

Stereoselective anti-SN2′ Mitsunobu reaction of α-hydroxy-α-alkenylsilanes

A novel silyl group-directed anti-SN2′ reaction of allylic alcohols under Mitsunobu reaction conditions is described. The Mitsunobu reaction of α-hydroxy-α-alkenylsilanes with a TBS or TIPS group gave the anti-SN2′ product, in which regio- and stereochemical outcomes of the reaction depended on the steric bulkiness of the silyl group.

Hg(OTf)2-catalyzed arylene cyclization

Novel Hg(OTf)2-catalyzed arylene cyclization was achieved with highly efficient catalytic turnover (up to 200 times). The reaction takes place via protonation of allylic hydroxyl group by in situ formed TfOH of an organomercurlc intermediate to

(+)-Zaragozic acid C: Synthesis and related studies

The asymmetric synthesis of the potent squalene synthase inhibitor (+)-zaragozic acid C is described. The synthesis allows for the preparation of multigram quantities of the dioxabicyclooctane core common to all members of this class of fungal metabolites. Supporting studies include (1) the use of [Cr(OAc)2·H2O]2 for the stereoselective reduction of ynones to trans enones, (2) an investigation of the diastereoselective dihydroxylation of γ-alkoxy-α,β-trans enones, and (3) nucleophilic addition of Me3SiC≡CLi to a dioxabicyclooctanone, wherein the product diastereoselectivity is observed to vary as a function of cosolvents (tertiary amines) and additives (LiBr). In addition, an acylation protocol is reported which permits the regioselective installation of the C(6) O-acyl side chain.

Palladium-Catalyzed Cross-Coupling of Aryl Halides and Olefinic Epoxides via Palladium Migration

The palladium-catalyzed cross-coupling of aryl halides and olefinic epoxides bearing one to ten carbons between the two functional groups afford good yields of arylated allylic alcohols by a palladium migration process.