130190-59-9Relevant academic research and scientific papers
α-(Dialkylamino)-α-pyrrolylacetonitriles. A potpourri of useful synthetic transformations
Bray, Brian L.,Muchowski, Joseph M.
, p. 1305 - 1308 (2007/10/02)
α-(Dialkylamino)-α-(pyrrol-2-yl)acetonitriles (3) are versatile intermediates that are readily converted into regiochemically pure 2-bromo-6-dialkylamino-1-azafulvenes and 5-bromo-2-acylpyrroles (acyl= CHO, COR).In addition, 3 (R1= H), 4 (R1= H), and the β-substituted compound 9 are transformed easily and under mild conditions, via the corresponding α-methylthio compounds (e.g., 7a), into the methyl pyrrole carboxylates 8a, 8b, and 10, respectively.
