130190-60-2Relevant academic research and scientific papers
Oxidative Halogenation of Substituted Pyrroles with Cu(II). Part III. Bromination and Chlorination of 2-Benzoylpyrrole
Petruso, S.,Caronna, S.
, p. 355 - 357 (2007/10/02)
The bromination of 2-benzoylpyrrole with copper (II) bromide in the homogenous and heterogenous phase is described, giving 4- and 5-monobromo derivatives whose ratio decreases as the temperature is increased.The same reaction with copper(II) chloride in acetonitrile at 60 deg C produces 5-chloro-2-benzoylpyrrole as the major product. 4,5-Dihalopyrroles in good yields are obtained with an excess of halogenating agent.
α-(Dialkylamino)-α-pyrrolylacetonitriles. A potpourri of useful synthetic transformations
Bray, Brian L.,Muchowski, Joseph M.
, p. 1305 - 1308 (2007/10/02)
α-(Dialkylamino)-α-(pyrrol-2-yl)acetonitriles (3) are versatile intermediates that are readily converted into regiochemically pure 2-bromo-6-dialkylamino-1-azafulvenes and 5-bromo-2-acylpyrroles (acyl= CHO, COR).In addition, 3 (R1= H), 4 (R1= H), and the β-substituted compound 9 are transformed easily and under mild conditions, via the corresponding α-methylthio compounds (e.g., 7a), into the methyl pyrrole carboxylates 8a, 8b, and 10, respectively.
