130219-69-1Relevant academic research and scientific papers
Electrostatic Control of Regioselectivity in Au(I)-Catalyzed Hydroarylation
Lau, Vivian M.,Pfalzgraff, William C.,Markland, Thomas E.,Kanan, Matthew W.
supporting information, p. 4035 - 4041 (2017/03/31)
Competing pathways in catalytic reactions often involve transition states with very different charge distributions, but this difference is rarely exploited to control selectivity. The proximity of a counterion to a charged catalyst in an ion paired comple
Improved Synthesis of Aryl 1,1-Dimethylpropargyl Ethers
Godfrey, Jollie D.,Mueller, Richard H.,Sedergran, Thomas C.,Soundarajan, Nachimuthu,Colandrea, Vincent J.
, p. 6405 - 6408 (2007/10/02)
An efficient, general, and practical synthesis of aryl 1,1-dimethylpropargyl ethers has been developed.
Relaxant Activity of 4-Amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-Amido-2H-1-benzopyrans on Guinea Pig Isolated Trachealis
Buckle, Derek R.,Arch, Jonathon R. S.,Fenwick, Ashley E.,Houge-Frydrych, Catherine S. V.,Pinto, Ivan L.,et al.
, p. 3028 - 3034 (2007/10/02)
A series of 4-amido-3,4-dihydro-2H-benzopyran-3-ols and 4-amido-2H-1-benzopyrans related to the potassium channel activator cromakalim have been prepared and evaluated for their relaxant activity in guinea pig isolated tracheal spirals.Several analogues show enhanced relaxant activity relative to cromakalim in this preparation and the rank order of potency for those substituents investigated at C-6 was CF3>CN>C2H5>aza>=CH3.One compound, trans-3,4-dihydro-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-7-(trifluoromethyl)-2H-1-benzopyran-3-ol (24), was resolved into its two enantiomers and the activity was shown to reside essentially in the (+)-isomer, adding further support to the suggestion that the smooth muscle receptor for these potassium channel activators is stereoselective.
