130224-40-7Relevant academic research and scientific papers
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4- d]pyrimidin-4-one inhibitors of cyclin-dependent kinases
Markwalder, Jay A.,Arnone, Marc R.,Benfield, Pamela A.,Boisclair, Michael,Burton, Catherine R.,Chang, Chong-Hwan,Cox, Sarah S.,Czerniak, Philip M.,Dean, Charity L.,Doleniak, Deborah,Grafstrom, Robert,Harrison, Barbara A.,Kaltenbach III, Robert F.,Nugiel, David A.,Rossi, Karen A.,Sherk, Susan R.,Sisk, Lisa M.,Stouten, Pieter,Trainor, George L.,Worland, Peter,Seitz, Steven P.
, p. 5894 - 5911 (2007/10/03)
Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]-pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC50
