130232-56-3

Upstream product

• 106-69-4 hexane-1,2,6-triol 
• 122872-99-5 4-((S)-2,2-dimethyl-1,3-dioxoaln-4-yl)butan-1-ol 
• 821-41-0 5-Hexen-1-ol 
• 942304-04-3 palmerolide (A) 
• 136963-34-3 methyl 4-bromo-5,6-O-isopropylidene-2,3,4-trideoxy-D-threo-hexonate 
• 103367-30-2 methyl (5S)-5,6-O-isopropylidene-5,6-dihydroxyhexanoate 
• 127529-99-1 (S)-Chloro-((4R,5S,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-acetic acid methyl ester 
• 127553-90-6 methyl 2,3-dideoxy-5,6-O-isopropylidene-D-erythro-hexonate 

Relevant academic research and scientific papers

On the stereochemistry of palmerolide A

Degradative studies of the anticancer macrolide palmerolide A have resulted in re-assignment of the C-7, C-10, and C-11 stereocenters.

Dispiroketals in synthesis (part 9): Resolution of 1,2-diols using a C2-symmetric diphenyltetrahydrobipyran

A series of 1,2-diols were resolved by the enantioselective formation of the thermodynamically most stable dispiroketal using (2R,2'R) and (2S,2'S) 2,2'-diphenyl-3,3',4,4'-tetrahydro-6,6'-bi-2H-pyran 2 and 3. Deprotection was achieved using a metal ammonia reduction to liberate the resolved diols.

Synthesis of some trideoxy-D-hexoses and derivatives thereof from D-glucono-1,5-lactone

Enantiospecific syntheses of methyl 2,3,4-trideoxy-α-D- and β-D-glycero-hexopyranoside (10 and 11), methyl α-D- and β-D-amicetopyranoside (24 and 25), (2S)-1,2-hexanediol (36), (2S)-1,2,6-hexanetriol (37), and some derivatives thereof from D-glucono-1,5-lactone are described. Enantiospecific syntheses of methyl 2,3,4-trideoxy-α-D- and -β-D-glycero-hexopyranoside (10 and 11), methyl α-D- and β-D-amicetopyranoside (24 and 25), (2S)-1,2-hexanediol (36), (2S)-1,2,6-hexanetriol (37), and some derivatives thereof from D-glucono-1,5-lactone are described.