130239-66-6Relevant articles and documents
Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives
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, (2008/06/13)
Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
Quinazolinone derivatives
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, (2008/06/13)
Compounds of the formula (1) : and pharmaceutically acceptable salts thereof are described wherein R1 is C1 6alkyl, C2 6alkenyl, C3 5-cycloalkylC1 4alkyl, phenylC1 4alkyl or C1 4alkyl substituted by 1 to 6 fluoro groups; R2 is hydrogen, C1 6alkyl, C1 6-alkylthio, C1 6alkoxy, nitro or -NR3R4; and R3 and R4 are independently hydrogen or C1 4alkyl optionally sub-stituted by hydroxy provided that the carbon atom adjacent to the nitrogen atom is not substituted by hydroxy; with the proviso that R1 is not methyl or ethyl when R2 is hydrogen. Processes for their preparation, pharmaceutical compositions containing them and their use as medicaments are described.