130247-17-5

Upstream product

• 130247-16-4 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene 
• 589-87-7 1,4-bromoiodobenzene 
• 130247-01-7 methyl 2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)acrylate 
• 121750-77-4 2-(trimethylsilyl)ethyl-p-nitrophenyl carbonate 
• 130274-20-3 1-<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-4-bromobenzene 
• 130247-18-6 N-<<2-(trimethylsilyl)ethoxy>carbonyl>serine methyl ester 
• 94882-75-4 benzyl (2-t-butoxycarbonylamino)acrylate 

Relevant academic research and scientific papers

Synthesis of optically active arylene bis-alanine derivatives carrying orthogonal protecting groups

Derivatives of para- and meta-phenylene bis-alanine and related biphenyl systems, carrying four orthogonal protecting groups, were synthesised via combinations of Heck couplings and asymmetric hydrogenations. The intermediate unsaturated arylalanine derivatives were hydrogenated using [Rh(COD)((R,R)-DIPAMP)]+BF4- or [Rh(COD)(Me-DuPHOS)]+X- as catalysts to produce the optically active, protected amino acid derivatives in ≤98% e.e. as analysed by chiral phase HPLC.