1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

Base Information

Chemical Name:1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene
CAS No.:130247-17-5
Molecular Formula:C₃₁H₄₄N₂O₈Si
Molecular Weight:600.784
Hs Code.:

1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

Synonyms:1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

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Chemical Property of 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

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Technology Process of 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

There total 7 articles about 1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 130247-16-4
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethenyl]benzene

: 130247-17-5
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

Guidance literature:: With hydrogen; Wilkinson's catalyst; In ethanol; at 50 ℃; for 120h; under 3040 Torr;
DOI:10.1021/jo00003a065

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 130247-17-5
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

2: 62 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

3: 50 percent / H₂ / Rh(PPh₃)3Cl / ethanol / 120 h / 50 °C / 3040 Torr

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; palladium diacetate; Wilkinson's catalyst; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00003a065

Reference yield:

: 94882-75-4
benzyl (2-t-butoxycarbonylamino)acrylate

: 130247-17-5
1-{2-(benzyloxycarbonyl)-2-[(tert-butoxycarbonyl)amino]ethenyl}-4-[2-(methoxycarbonyl)-2-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)ethyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

2: 62 percent / Bu₄NCl, NaHCO₃ / Pd(OAc)2 / dimethylformamide / 16 h / 85 °C

3: 50 percent / H₂ / Rh(PPh₃)3Cl / ethanol / 120 h / 50 °C / 3040 Torr

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; palladium diacetate; Wilkinson's catalyst; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00003a065