130250-38-3

Upstream product

• 134934-18-2 Ethyl 4-O-(tert-butyldimethylsilyl)-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside 
• 125816-07-1 <5S-(5α,6β)>-5-<(tert-Butyldimethylsilyl)oxy>tetrahydro-6-(cyclohexylmethyl)-2H-pyran-2-one 
• 138588-18-8 (4S,5S)-5-((1S,2S)-2-tert-Butylsulfanylcarbonyl-1-hydroxy-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 138588-17-7 ((1-(tert-butylthio)-3-methylbut-1-en-1-yl)oxy)trimethylsilane 
• 138588-20-2 (4R,5S)-5-[(1R,2S)-2-tert-Butylsulfanylcarbonyl-1-(imidazole-1-carbothioyloxy)-3-methyl-butyl]-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 112190-41-7 (4R,5R)-4-Cyclohexylmethyl-5-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 138588-21-3 (4R,5R)-5-((R)-2-tert-Butylsulfanylcarbonyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 3323-72-6 ethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythrohex-2-enopyranoside 
• 134922-54-6 <5S-(5α,6β),3(Z)>-5-<(tert-Butyldimethylsilyl)oxy>tetrahydro-6-(cyclohexylmethyl)-3-ethylidene-2H-pyran-2-one 
• 134922-50-2 <5S-(5α,6β),3(E)>-5-<(tert-Butyldimethylsilyl)oxy>tetrahydro-6-(cyclohexylmethyl)-3-ethylidene-2H-pyran-2-one 
• 125816-08-2 <3S-(3α,5α,6β)>-5-<(tert-Butyldimethylsilyl)oxy>tetrahydro-6-(cyclohexylmethyl)-3-isopropyl-2H-pyran-2-one 
• 125816-12-8 <3R-(3α,5β,6α)>-5-<(tert-Butyldimethylsilyl)oxy>tetrahydro-6-(cyclohexylmethyl)-3-isopropyl-2H-pyran-2-one 
• 134922-55-7 <3R-<3α,5α(S^*)>>-5-(2-Cyclohexyl-1-hydroxyethyl)dihydro-3-isopropyl-2(3H)-furanone 
• 134922-58-0 Methanesulfonic acid 1-[(5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-6-cyclohexylmethyl-2-oxo-tetrahydro-pyran-3-yl]-ethyl ester 

Downstream Products

• 134922-51-3 <2R,4S,5S>-6-Cyclohexyl-5-<(N-cyclohexyl-N-methyl)glycyl-3-(1-naphthyl)-L-alanyl-3-(4-thiazolyl)-L-alanyl)amino>-4-hydroxy-2-isopropylhexanoyl-<2-(4-morpholino)ethyl>amide 

Relevant academic research and scientific papers

Synthesis of renin inhibitors possessing hydroxyethylene isostere residue from 3,4,6-tri-O-acetyl-D-glucal via lactone precursor

Syntheses of precursors for renin inhibitors possessing hydroxyethylene isostere residue from 2,4,6-tri-O-acetyl-D-glucal via lactone precursor is described . This route makes it possible to synthesize analogues with various substituents at C-2 and C-5 of

A Stereoselective Synthesis of Hydroxyethylene and erythro-Dihydroxyethylene Dipeptide Isosteres: A Facial Selective anti-Aldol Reaction

A Lewis-acid catalyzed anti-aldol reaction of aldehyde 4 afforded diol 6a (95percent de).Aminolysis of the corresponding β-lactone provided erythro-dihydroxyethylene dipeptide isostere 2 while the lactone-protected hydroxyethylene dipeptide isostere 3 was obtained through selective deoxygenation and acidic deprotection. Key words: hydroxyethylene isostere; anti-aldol; aspartic proteinase; renin inhibitor; facial selective