130256-29-0Relevant academic research and scientific papers
ENANTIOTOPOSELECTIVE PLE-CATALYZED HYDROLYSIS OF CIS-5-SUBSTITUTED-1,3-DIACYLOXYCYCLOHEXANES. PREPARATION OF SOME USEFUL CHIRAL BUILDING BLOCKS
Carda, M.,Eycken, J. Van der,Vandewalle, M.
, p. 17 - 20 (1990)
PLE-catalyzed hydrolysis of prochiral cis-5-benzyloxymethyl-1,3-diacetoxycyclohexane and cis-5-benzyloxy-1,3-diacetoxycyclohexane proceeds with high enantiotoposelectivity.The preparation of some useful chiral building blocks is described.
Enzymatic Desymmetrization of 19-nor-Vitamin D3 A-Ring Synthon Precursor: Synthesis, Structure Elucidation, and Biological Activity of 1α,25-Dihydroxy-3-epi-19-nor-vitamin D3 and 1β,25-Dihydroxy-19-nor-vitamin D3
González-García, Tania,Verstuyf, Annemieke,Verlinden, Lieve,Fernández, Susana,Ferrero, Miguel
, p. 2762 - 2772 (2018/07/29)
In a search for novel vitamin D derivatives of potential therapeutic value, structurally simple but synthetically challenging A-ring epimers of the 19-nor-Calcitriol [19-nor-1α,25-(OH)2-D3] at C1 and C3 were efficiently synthesized. Both analogues (1-epi- and 3-epi-19-nor-Calcitriol) were obtained through a convergent synthesis starting from cis,cis-1,3,5-cyclohexanetriol and the protected 25-hydroxy Grundmann′s ketone. After Julia-Kocienski coupling of the corresponding C,D-ring/side chain sulfone fragment with the A-ring ketone moiety, both vitamin D analogues were isolated. The critical point was how to determine the structural configuration of both diastereoisomers since similar 1H NMR spectra were observed. For that, a biocatalytic approach was crucial in the synthesis of orthogonally protected derivatives. NMR spectroscopy allows the unambiguous identification of these compounds and as a result the structural elucidation of the desired vitamin D diastereomeric analogues. Affinity studies demonstrated that these 1,25-19-nor analogues have a very low affinity for the vitamin D receptor compared with 1α,25-dihydroxyvitamin D3 or 1α,25-dihydroxy-19-nor-vitamin D3. In addition, these analogues have a lower binding affinity for the human vitamin D binding protein than the natural hormone. In vitro cell culture studies revealed that synthesized analogues were less active than 1α,25-dihydroxyvitamin D3 in inhibiting cell proliferation. (Figure presented.).
