130274-69-0

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 121444-55-1 2-(tert-Butyldimethylsilyl)-1,2-thiazetidine 1,1-dioxide 
• 148588-16-3 (E)-4-(α-aminobenzylidene)-2-(tert-butyldimethylsilyl)-1,2-thiazetidine 1,1-dioxide 
• 100-47-0 benzonitrile 

Downstream Products

• 753018-78-9 phenyl 2-[(tert-butyl)dimethylsilyl]-4-[1,2-bis(ethoxycarbonyl)hydrazino]-1,2-thiazetidine-4-carboxylate 1,1-dioxide 
• 1476078-14-4 1-(4-benzoyl-1,1-dioxido-1,2-thiazetidin-2-yl)ethanone 
• 130274-87-2 (αS^*,4S^*)-2-(tert-butyldimethylsilyl)-4-(α-hydroxybenzyl)-1,2-thiazetidine 1,1-dioxide 
• 130274-75-8 (αR^*,4S^*)-2-(tert-butyldimethylsilyl)-4-(α-hydroxybenzyl)-1,2-thiazetidine 1,1-dioxide 
• 130274-70-3 4-Benzoyl-1,2-thiazetidine 1,1-dioxide 

Relevant academic research and scientific papers

β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues

β-Sultams are potent electrophiles that modify nucleophilic residues in selected enzyme active sites. We here identify and characterize some of the specific bacterial targets and show a unique inhibition of the azoreductase family.

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

Over 100 protease inhibitors are currently used in the clinics, and most of them use blockage of the active site for their mode of inhibition. Among the protease drug targets are several enzymes for which the correct multimeric assembly is crucial to thei

Properties and reactions of substituted 1,2-thiazetidine 1,1-dioxides: Functionalization and reactions at C(4) of the β-sultam

The introduction of functional groups at the 4-position of β-sultam ring was realized by the synthesis of mono- and disubstituted derivatives by reactions of N-silylated β-sultams with electrophiles in the presence of BuLi or LDA. As electrophiles, ketone

SYNTHESIS AND REACTIONS OF 4-(α-AMINOARYLIDENE)THIAZETIDINE 1,1-DIOXIDES

β-Sultams react as highly potent sulfonyl analogues of β-lactams with aromatic nitriles to the title compounds (2).Hydrolysis, reduction, and reactions of 2 with acylating and alkylating agents are described.Some of the compounds show a weak β-lactamase i

Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Acylation of β-Sultams at C-4, Reduction of 4-Acyl-β-sultams, and Stereochemistry of 4-(α-Hydroxyalkyl)-β-sultams

Acylation of N-silylated and 2,3-substituted 1,2-thiazetidine 1,1-dioxides (β-sultams) results in the formation of 4-acylated β-sultams 2 and 8.The desilylation of 2 to 3 is easily done with TBAF either on silica gel or in ethanolic solution.The acylated