130277-94-0

Upstream product

• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 
• 65-85-0 benzoic acid 
• 613-90-1 benzoyl cyanide 
• 186348-58-3 S-(-)-3-phthalimido-1,2-propanediol 
• 1074-82-4 potassium phtalimide 
• 40137-25-5 1H-isoindole-1,3(2H)-dione, 2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl] 

Downstream Products

• 130277-96-2 2-(chloromethoxy)-3-(phthalimido)propyl benzoate 
• 119835-91-5 S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzoyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 119835-95-9 S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine 
• 119835-96-0 S-(-)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil 
• 119835-90-4 Benzoic acid (R)-2-chloromethoxy-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl ester 

Relevant academic research and scientific papers

The syntheses of purine and pyrimidine secoribo-nucleosides: Acyclo-uridine derivative of cyclophosphamide

The synthesis of secoribo-nucleoside analogues is described. Compounds 4 and 5 possess interesting antiviral effects in vitro. A procedure is also developed for the conversion of acyclo-uridine nucleoside 7 to a novel derivative of cyclophosphamide 8.

Synthesis of enantiomers of 2'-aminomethyl-5-benzylacyclouridine (AM-BAU) and 2'-aminomethyl-5-benzyloxybenzylacyclouridine (AM-BBAU). Potent inhibitors of uridine phosphorylase

Racemic 2'-aminomethyl-5-benzyl-acyclouridine (AM-BAU, 5) and 2'-aminomethyl-5-benzyloxybenzylacyclouridine (AM-BBAU, 6) have been found to be very active inhibitors of uridine phosphorylase [1]. Their enantiomers were synthesized from chiral 2,2-dimethyl