130286-65-6

Upstream product

• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 109-77-3 malononitrile 

Downstream Products

• 1227858-42-5 4-(4-phenylthiazol-2-yl)-1H-pyrazole-3,5-diamine 
• 617699-65-7 2-(4-phenyl-5-phenylazo-3H-thiazol-2-ylidene)malononitrile 
• 1290604-53-3 2,7-diamino-5-phenyl-3-(4-phenylthiazol-2-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile 
• 1290604-55-5 N-(2-dicyanomethylene-4-phenyl-2,3-dihydrothiazol-5-yl)acetamide 
• 1290604-57-7 2-(5-benzylidene-4-phenylthiazol-2(5H)-ylidene)malononitrile 
• 1396320-30-1 (E)-3-amino-3-(4-methylphenylamino)-2-(4-phenylthiazol-2-yl)acrylonitrile 
• 1396320-21-0 (E)-3-amino-3-dimethylamino-2-(4-phenylthiazol-2-yl)acrylonitrile 
• 1396320-11-8 (E)-3-amino-3-morpholin-4-yl-2-(4-phenylthiazol-2-yl)acrylonitrile 
• 1396320-16-3 (E)-3-amino-2-(4-phenylthiazol-2-yl)-3-piperidin-1-yl-acrylonitrile 
• 1260019-65-5 N-[(1E,3Z)-3-(2-(dicyanomethylene)-4-phenylthiazol-2-ylidene)prop-1-enyl]-N-phenylacetamide 
• 1260019-66-6 N-[(1E,3E,5Z)-5-(2-dicyanomethylene-4-phenylthiazol-2-ylidene)penta-1,3-dienyl]-N-phenylacetamide 
• 1260019-63-3 2-[(Z)-5-((2E,4Z)-4-(3-ethylbenzothiazol-2-ylidene)but-2-enylidene)-4-phenylthiazol-2-ylidene]malononitrile 
• 1260019-62-2 2-[(Z)-5-((Z)-2-(3-ethylbenzothiazol-2-ylidene)ethylidene)-4-phenylthiazol-2-ylidene]malononitrile 

Relevant academic research and scientific papers

Antimicrobial activities of some novel thiazoles

2-(4-Phenylthiazol-2(3H)-ylidene)-malononitrile was synthesized by treating 1-phenyl-2-thiocyanatoethanone with malononitrile. Reaction of 2-(4-phenylthiazol-2(3H)-ylidene)-malononitrile with hydrazine hydrate afforded 4-(4-phenylthiazol-2-yl)-1H-pyrazole

Dimedone-catalyzed addition of amines into cyano group: Facile synthesis of thiazol-2-yl substituted E-acrylonitriles

An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of α-thiocyanate ketones with malononitrile and amines. The α-thiocyanate ketones were s

Reassignment of the structures of products produced by reactions of the product believed to be 2-(1-phenyl-2-thiocyanatoethylidene)-malononitrile with electrophiles

The reactivity of the product believed to be 2-(1-phenyl-2- thiocyanatoethylidene) malononitrile toward a variety of electrophilic and nucleophilic reagents is reported.

Polyfunctional heteroaromatics: A route to dicyanomethylene thiazoles based on the reaction of α-thiocyanatoketones with malononitrile

Reactions of α-S-cyanothioketones 6a-c with malononitrile were observed to form 2-(thiazol-2(3H)-ylidene)malononitrile derivatives 7a-c. The thiazole products readily react with aromatic diazonium salts to yield 2-(5-phenylazo-3H-thiazol-2-ylidene)-malononitrile derivatives 8a-c. The malononitrile derivative 8c undergoes a condensation with DMF/DMA to yield thiazolo[5,4-c]pyridazine 12. Reactions of 7a-c with hydrazine hydrate leads to the generation of diaminopyrazoles 9a-c, which react with enaminone 13 to yield the corresponding thiazolylpyrazolo[1,5-a]pyrimidines 14. In addition, reaction of the malononitrile derivative 8a with benzenediazonium chloride readily affords the coupling product 10. ARKAT USA, Inc.