617699-65-7

Upstream product

• 130286-65-6 2-dicyanomethylene-2,3-dihydro-4-phenylthiazole 
• 100-34-5 benzene diazonium chloride 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 

Downstream Products

• 1227858-48-1 4-(4-phenyl-5-phenylazo-thiazol-2-yl)-1H-pyrazol-3,5-diamine 
• 1290604-55-5 N-(2-dicyanomethylene-4-phenyl-2,3-dihydrothiazol-5-yl)acetamide 

Relevant academic research and scientific papers

Antimicrobial activities of some novel thiazoles

2-(4-Phenylthiazol-2(3H)-ylidene)-malononitrile was synthesized by treating 1-phenyl-2-thiocyanatoethanone with malononitrile. Reaction of 2-(4-phenylthiazol-2(3H)-ylidene)-malononitrile with hydrazine hydrate afforded 4-(4-phenylthiazol-2-yl)-1H-pyrazole

Reassignment of the structures of products produced by reactions of the product believed to be 2-(1-phenyl-2-thiocyanatoethylidene)-malononitrile with electrophiles

The reactivity of the product believed to be 2-(1-phenyl-2- thiocyanatoethylidene) malononitrile toward a variety of electrophilic and nucleophilic reagents is reported.

Polyfunctional heteroaromatics: A route to dicyanomethylene thiazoles based on the reaction of α-thiocyanatoketones with malononitrile

Reactions of α-S-cyanothioketones 6a-c with malononitrile were observed to form 2-(thiazol-2(3H)-ylidene)malononitrile derivatives 7a-c. The thiazole products readily react with aromatic diazonium salts to yield 2-(5-phenylazo-3H-thiazol-2-ylidene)-malononitrile derivatives 8a-c. The malononitrile derivative 8c undergoes a condensation with DMF/DMA to yield thiazolo[5,4-c]pyridazine 12. Reactions of 7a-c with hydrazine hydrate leads to the generation of diaminopyrazoles 9a-c, which react with enaminone 13 to yield the corresponding thiazolylpyrazolo[1,5-a]pyrimidines 14. In addition, reaction of the malononitrile derivative 8a with benzenediazonium chloride readily affords the coupling product 10. ARKAT USA, Inc.