13029-29-3

Usage

Structure

A six-carbon chain with two amine functional groups (-NH2) and two ethyl groups (-CH2CH3) attached to the nitrogen atoms.

Applications

Curing agent in epoxy resins
Cross-linking agent in polyurethane elastomers
Manufacturing of adhesives, coatings, and sealants
Potential use as a corrosion inhibitor
Component in the synthesis of pharmaceuticals and agrochemicals

Health and Environment

Potential harmful effects on human health
Potential harmful effects on the environment
Requires cautious handling and proper safety measures during use and disposal.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 64-17-5 ethanol 
• 63945-11-9 6-phthalimido-1-hexanol 

Downstream Products

• 754227-35-5 hexanedioic acid (4-amino-phenyl)-amide (6-diethylamino-hexyl)-amide 
• 158094-54-3 N,N-diethyl-N'-benzyl-1,6-hexanediamine 
• 158094-55-4 N-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>-benzodiazepin-11-yl)carbonyl>methyl>-N-benzyl-N',N'-diethyl-1,6-hexanediamine 
• 790632-91-6 N,N-diethyl-N'-(2-methoxybenzyl)-1,6-hexanediamine 

Relevant academic research and scientific papers

METHOD FOR PRODUCING N-MONOALKYL-SUBSTITUTED ALKYLENE AMINE

PROBLEM TO BE SOLVED: To provide a method for producing an N-monoalkyl-substituted alkylene amine especially useful for uses such as medicine intermediates, agrochemical intermediates, urethane resin-foaming catalysts, surfactants and the like among alkyl-substituted alkylene amine compounds from an alcohol and an alkylene amine as raw materials. SOLUTION: This method for producing the N-monoalkyl-substituted alkylene amine is characterized by reacting the alkylene amine with a ≥2C alkyl alcohol in the presence of a copper-containing oxide catalyst system. The N-monoalkyl-substituted alkylenamine is produced in high conversion and in N-monoalkylation selectivity.

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors

Telomerase and telomere maintenance are emerging targets for the treatment of human cancers. We report here on the targeting of the telomere-telomerase complex with a series of small molecules based on an acridine platform. A series of 3,6-bisamidoacridines with extended 9-anilino sidechains were designed and synthesised as potential telomeric G-quadruplex DNA (G4) interacting compounds. G4-stabilisation was assessed using a high-throughput FRET (fluorescence resonance energy transfer) assay and telomerase inhibition quantified by a modified TRAP (telomerase repeat amplification protocol) method. Within the series, the compounds showed significant G4-stabilising ability (ΔT m values of 25-36°C at 1μM concentration) and telomerase inhibition in the nanomolar region (telEC50 values of 80-318nM). Furthermore, a direct correlation between the FRET and TRAP assays was observed, supporting the use of the rapid screening FRET assay for early assessment of potential G4-stabilising telomerase inhibitors.