130291-44-0

Upstream product

• 130291-43-9 C₃₅H₄₀O₈S₂ 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 169870-39-7 ((2S,6S)-1-Benzyl-6-hydroxymethyl-piperidin-2-yl)-methanol 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 
• 59234-46-7 dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 
• 130291-41-7 1,7-bis(benzyloxy)-4-benzenesulfonyl-(2R,6R)-heptanediol 
• 130291-42-8 (2R,6R)-1,7-Bis-benzyloxy-heptane-2,6-diol 
• 3112-85-4 methylphenylsulfonate 
• 87109-89-5 Dimethyl cis-N-benzyl-2,6-piperidinedicarboxylate 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 

Downstream Products

• 130291-37-1 (2S,6S)-(-)-2,6-bis(benzyloxymethyl)piperidine 

Relevant academic research and scientific papers

Highly enantioselective synthesis of substituted piperidines using the chiral lithium amide base approach

The symmetry-breaking enolisation reaction of a meso-piperidine diester using a chiral bis-lithium amide base allows access to alkylated derivatives in highly diastereo- and enantioselective fashion (> 98% ee).

New entry to C2 symmetric trans-2,6-bis(hydroxymethyl)-piperidine derivatives via the Sharpless asymmetric dihydroxylation

A new synthesis of both enantiomers of C2-symmetric trans-2,6-bis(hydroxymethyl)piperidine derivatives 1 by the use, as a key reaction, of the Sharpless asymmetric dihydroxylation of a symmetric diene 2 is presented.

Synthesis of (2R,6R)-(-)-2,6-Lupetidine: 2,6-disubstituted piperidines as potentially useful 'C2-symmetric' chiral reagents

(2R,6R)-(-)-2,6-Lupetidine has been synthesized from (S)-1,2-epoxypropane and (2S,6S)-(-)-2,6-bis(benzyloxymethyl)piperidine has been synthesized from (S)-benzyloxymethyl oxirane.