130307-88-9Relevant academic research and scientific papers
A simple efficient method of preparing efavirenz intermediates
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Paragraph 0068-0070, (2018/02/04)
The invention relates to a method for simply and efficiently preparing efavirenz intermediates, which belongs to the technical field of organic compound catalytic chemistry. The method is used for the high-yield preparation of a series of efavirenz interm
Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis
Zheng, Yu,Tan, Yuqi,Harms, Klaus,Marsch, Michael,Riedel, Radostan,Zhang, Lilu,Meggers, Eric
supporting information, p. 4322 - 4325 (2017/04/06)
A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%).
A ligand-free strategy for the copper-catalysed direct alkynylation of trifluoromethyl ketones
Wang, Lei,Liu, Ning,Dai, Bin,Ma, Xiaowei,Shi, Lei
, p. 10089 - 10093 (2015/02/05)
Most direct alkynylation methods of trifluoromethyl ketones require an additional ligand. In this study, a simple, practical and efficient superbase system for the direct alkynylation of trifluoromethyl ketones was developed without any additional ligand.
C1-symmetric Rh/Phebox-catalyzed asymmetric alkynylation of α-ketoesters
Ohshima, Takashi,Kawabata, Takahito,Takeuchi, Yosuke,Kakinuma, Takahiro,Iwasaki, Takanori,Yonezawa, Takayuki,Murakami, Hajime,Nishiyama, Hisao,Mashima, Kazushi
supporting information; experimental part, p. 6296 - 6300 (2011/09/13)
Thinking outside the box: A newly developed C1-symmetric Rh/Phebox complex efficiently catalyzed the asymmetric alkynylation of α-ketoester 1 with various aryl and alkyl substituted terminal alkynes to provide the corresponding chiral tertiary propargylic alcohols with up to 99 % ee (see scheme; TMS=trimethylsilyl). Copyright
Efficient direct alkynylation of trifluoromethyl ketones catalyzed by agf in water and organic solvents
Deng, Guo-Jun,Li, Chao-Jun
experimental part, p. 1571 - 1573 (2009/04/07)
A general and efficient method for the direct alkynyla-tion of trifluoropyruvate and trifluoroacetophenone in water was developed by using AgF and PCy3 as a catalyst. The ligand en-hanced the catalyst activity significantly. The reaction in water is comparable to the one carried out in organic solvents.
Catalytic aerobic oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones
Blay, Gonzalo,Fernández, Isabel,Marco-Aleixandre, Alicia,Monje, Belén,Pedro, José R,Ruiz, Rafael
, p. 8565 - 8571 (2007/10/03)
The oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones is carried out under mild catalytic aerobic conditions using a cobalt(III) complex in the presence of pivalaldehyde.
α-Trifluoromethyl Substituted α-Hydroxy Acids with Alkyne Functions in the Side Chain
Sewald, Norbert,Burger, Klaus
, p. 871 - 875 (2007/10/02)
Trifluoromethyl substituted α-hydroxy acids with alkyne functions in the side chain are obtained on reaction of trifluoro pyruvates with alkynyl Grignard reagents and alkali metal salts of alkynes, respectively.
