130327-74-1

Upstream product

• 130327-72-9 N-(6-Nitro-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl)-acetamide 
• 130327-73-0 2-acetamido-6-amino-3,4-dihydro-4-oxopyrido<2,3-d>pyrimidine 
• 56277-36-2 diethyl 4-formylbenzoyl-L-glutamate 

Downstream Products

• 130327-68-3 N⁽⁹⁾-methyl-5-deazaisofolic acid 
• 170470-96-9 5-deaza-5,6,7,8-tetrahydroisofolic acid 
• 130327-69-4 N⁽⁹⁾-formyl-5-deazaisofolic acid 
• 170470-97-0 N⁽⁹⁾-methyl-5-deaza-5,6,7,8-tetrahydroisofolic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues

Prompted by recent disclosures concerning the potent antitumor activities of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), we have prepared 5-deazaisofolic acid (3a) and 5-deaza-5,6,7,8-tetrahydroisofolic aci