1303470-48-5 Usage
General Description
KHK-IN-1 (hydrochloride) is a chemical compound that has shown potential as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme involved in the conversion of cortisone to cortisol. This enzyme is implicated in various metabolic disorders such as obesity, type 2 diabetes, and metabolic syndrome. As a result, KHK-IN-1 (hydrochloride) has been studied for its potential therapeutic applications in these conditions. Additionally, KHK-IN-1 (hydrochloride) has been shown to have anti-inflammatory and anti-fibrotic properties, further expanding its potential uses in treating a range of diseases and conditions. Its promising pharmacological profile makes it a valuable compound for further research and development in the field of drug discovery and therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 1303470-48-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,3,4,7 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1303470-48:
(9*1)+(8*3)+(7*0)+(6*3)+(5*4)+(4*7)+(3*0)+(2*4)+(1*8)=115
115 % 10 = 5
So 1303470-48-5 is a valid CAS Registry Number.
1303470-48-5Relevant articles and documents
Inhibitors of ketohexokinase: Discovery of pyrimidinopyrimidines with specific substitution that complements the ATP-binding site
Maryanoff, Bruce E.,O'Neill, John C.,McComsey, David F.,Yabut, Stephen C.,Luci, Diane K.,Jordan Jr., Alfonzo D.,Masucci, John A.,Jones, William J.,Abad, Marta C.,Gibbs, Alan C.,Petrounia, Ioanna
, p. 538 - 543 (2011)
Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. We have
