1303470-48-5 Usage
Uses
Used in Pharmaceutical Industry:
KHK-IN-1 (hydrochloride) is used as a therapeutic agent for the treatment of metabolic disorders such as obesity, type 2 diabetes, and metabolic syndrome. It targets the 11β-HSD1 enzyme, thereby modulating the conversion of cortisone to cortisol, which is implicated in the development of these conditions.
Used in Anti-inflammatory Applications:
KHK-IN-1 (hydrochloride) is used as an anti-inflammatory agent due to its ability to reduce inflammation, which can be beneficial in treating a variety of inflammatory conditions.
Used in Anti-fibrotic Applications:
KHK-IN-1 (hydrochloride) is used as an anti-fibrotic agent to counteract the development of fibrosis in various tissues and organs, which can be a result of chronic inflammation or other pathological processes.
Used in Drug Discovery and Therapy Research:
KHK-IN-1 (hydrochloride) is used as a research compound for further exploration of its pharmacological properties and potential applications in drug discovery and therapy development, given its multifaceted effects on metabolic and inflammatory pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 1303470-48-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,3,4,7 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1303470-48:
(9*1)+(8*3)+(7*0)+(6*3)+(5*4)+(4*7)+(3*0)+(2*4)+(1*8)=115
115 % 10 = 5
So 1303470-48-5 is a valid CAS Registry Number.
1303470-48-5Relevant articles and documents
Inhibitors of ketohexokinase: Discovery of pyrimidinopyrimidines with specific substitution that complements the ATP-binding site
Maryanoff, Bruce E.,O'Neill, John C.,McComsey, David F.,Yabut, Stephen C.,Luci, Diane K.,Jordan Jr., Alfonzo D.,Masucci, John A.,Jones, William J.,Abad, Marta C.,Gibbs, Alan C.,Petrounia, Ioanna
, p. 538 - 543 (2011)
Attenuation of fructose metabolism by the inhibition of ketohexokinase (KHK; fructokinase) should reduce body weight, free fatty acids, and triglycerides, thereby offering a novel approach to treat diabetes and obesity in response to modern diets. We have
