130350-55-9Relevant academic research and scientific papers
A novel synthesis of ibutilide fumarate
Wang, Tao,Tian, Rui,Xiao, Bin,Shen, Yi,Zhou, Hui,Li, Qingeng
, p. 423 - 426 (2012/05/07)
A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.
N-[(ω-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with Class III antiarrhythmic activity
Hester,Gibson,Cimini,Emmert,Locker,Perricone,Skaletzky,Sykes,West
, p. 308 - 315 (2007/10/02)
N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluate the
