100632-81-3

Upstream product

• 863029-84-9 N-[4-(1-hydroxyallyl)phenyl]methanesulfonamide 
• 66793-76-8 ethyl(heptyl)amine 
• 201230-82-2 carbon monoxide 
• 1122-91-4 4-bromo-benzaldehyde 
• 1197-22-4 N-phenylmethanesulfonamide 
• 2687-91-4 1-ethyl-2-pyrrolidinone 
• 1329598-91-5 4-(N-ethyl-N-heptylamino)butanoylchloride hydrochloride 
• 208402-95-3 4-(ethylamino)butanoic acid hydrochloride 
• 1329598-96-0 4-(N-ethyl-N-heptylamino)butanoic acid hydrochloride 
• 629-06-1 1-Chloroheptane 
• 130350-55-9 N-[{4-(N-ethyl-N-heptylamino)butanoyl}phenyl]methanesulfonamide 
• 100632-57-3 4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 2403-53-4 2-(4-nitrophenyl)-1,3-dioxolane 

Downstream Products

• 122647-32-9 ibutilide hemifumarate 
• 145429-03-4 C₂₀H₃₅N₂O₂S⁽¹⁺⁾ 
• 130350-55-9 N-[{4-(N-ethyl-N-heptylamino)butanoyl}phenyl]methanesulfonamide 

Relevant academic research and scientific papers

A Multicatalytic Approach to the Hydroaminomethylation of α-Olefins

We report an approach to conducting the hydroaminomethylation of diverse α-olefins with a wide range of alkyl, aryl, and heteroarylamines at relatively low temperatures (70–80 °C) and pressures (1.0–3.4 bar) of synthesis gas. This approach is based on sim

A novel synthesis of ibutilide fumarate

A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.

Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation

(Chemical Equation Presented) We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.

HYDROAMINOMETHYLATION OF OLEFINS

The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.

Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides

The present invention provides novel sulfonanilide and benzene-alkylaminium compounds which are the products of processes utilizing novel intermediates. Both the novel compounds and the novel intermediates are useful for the therapeutic or prophylactic treatment of arrhythmic activity.

N-[(ω-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with Class III antiarrhythmic activity

N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluate the