130350-58-2

Upstream product

• 6328-00-3 4-(3-nitro-phenyl)-4-oxo-butyric acid 
• 66793-76-8 ethyl(heptyl)amine 
• 130350-57-1 N-Ethyl-N-heptyl-4-(3-nitro-phenyl)-4-oxo-butyramide 

Downstream Products

• 100633-01-0 N-[3-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide 
• 130377-67-2 N-ethyl-N-heptyl-3-<(methylsulfonyl)amino>-γ-hydroxybenzenebutanamide 

Relevant academic research and scientific papers

Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides

The present invention provides novel sulfonanilide and benzene-alkylaminium compounds which are the products of processes utilizing novel intermediates. Both the novel compounds and the novel intermediates are useful for the therapeutic or prophylactic treatment of arrhythmic activity.

N-[(ω-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with Class III antiarrhythmic activity

N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluate the