6328-00-3Relevant articles and documents
One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade
Bernhard, Yann,Gilbert, Joachim,Bousquet, Till,Favrelle-Huret, Audrey,Zinck, Philippe,Pellegrini, Sylvain,Pelinski, Lydie
supporting information, p. 7870 - 7873 (2019/12/24)
A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodology was applied on levulinic acid and derivatives, one of the biosourced platform chemicals.
Synthesis of different substituted pyridazinone derivatives and their anticonvulsant activity
Samanta, Kartick Chandra,Asif, Mohd.,Pooja,Garg, Vikas,Sharma, Priyanka,Singh, Ravinder
, p. 245 - 251 (2012/02/04)
6-Phenyl(3'-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3'-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.
Homogeneous catalysis of oxovanadium(IV) in the oxidation of substituted 4-oxo acids by bromate in acid medium: A mechanistic study
Reddy, Cherkupally Sanjeeva,Manjari, Padma Sunitha
experimental part, p. 76 - 87 (2010/11/18)
Oxovanadium(IV)-catalyzed oxidation of substituted 4-oxo-4-phenyl-butanoic acids (4-oxo acids) by bromate in acid medium leads to the formation of malonic acid and the corresponding benzoic acid. The reaction exhibits first order each in [bromate] and [acid], less than unity order each in [4-oxo acid] and [oxovanadium(IV)], and also shows solvent isotope effect (k(D 2O)/k(H2O) ～ 1.8). The reaction is failed to induce the polymerization of acrylonitrile. The decrease in the rate of reaction with increase in dielectric constant of the medium is observed with all the studied 4-oxo acids. Electron-releasing substituents in the phenyl ring accelerate the rate of oxidation to a large extent, the rate retardation by electron-withdrawing substituents, though perceptible, is not very much. The linear free-energy relationship is characterized by a smooth curve, concaves downward, in the Hammett's plot of log k versus σ, however, Hammett' plots are linear with excellent correlation coefficient, at four temperatures, when Brown and Okamoto's σ+ values are used. The ρ+ values are negative and decrease with increase in temperature. From the intersection of the lines in the Hammett and Arrhenius plots, the isokinetic relationship is discussed. The mechanistic pathway involving the cyclic oxidant-substrate-catalyst ternary complex is proposed, wherein the oxidation state of V(IV) is unaltered. The reaction is an example of the neighboring group participation and intramolecular catalysis.
