1303507-89-2Relevant academic research and scientific papers
Generation and reactivity of aza-oxyallyl cationic intermediates: Aza-[4 + 3] cycloaddition reactions for heterocycle synthesis
Jeffrey, Christopher S.,Barnes, Korry L.,Eickhoff, John A.,Carson, Christopher R.
, p. 7688 - 7691 (2011)
Aza-[4 + 3] cycloadditions of putative aza-oxyallyl cationic intermediates and cyclic dienes are reported. The intermediate is generated by the dehydrohalogenation of α-haloamides. The reaction is general to a variety of α-haloamides and is diastereoselective. Computational and experimental data suggest that an N-alkoxy substituent stabilizes the aza-oxyallyl cationic intermediate.
