1303575-52-1

Upstream product

• 553-90-2 Dimethyl oxalate 
• 1303573-81-0 N,3-dimethyl-4-nitro-N-phenylbenzenesulfonamide 
• 78726-75-7 3-methyl-4-nitrobenzene-1-sulfonyl chloride 
• 100-61-8 N-methylaniline 

Downstream Products

• 1303577-14-1 methyl 1-hydroxy-5-(N-methyl-N-phenylsulfamoyl)-1H-indole-2-carboxylate 
• 1303572-27-1 1-hydroxy-5-(N-methyl-N-phenylsulfamoyl)-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

N-Hydroxyindole-2-carboxylates possessing sulfonamide-substituents at either position 5 or 6 were designed and synthesized. The inhibitory activities of these compounds against isoforms 1 and 5 of human lactate dehydrogenase were analysed, and Ki values of the most efficient inhibitors were determined by standard enzyme kinetic studies. Some of these compounds displayed state-of-the-art inhibitory potencies against isoform 5 (Ki values as low as 5.6 μM) and behaved as competitive inhibitors versus both the substrate and the cofactor.