78726-75-7

Upstream product

• 93985-68-3 p-nitro-m-methylphenyl benzyl sulfide 
• 5367-28-2 5-chloro-2-nitrotoluene 

Downstream Products

• 129976-42-7 3-Methyl-4-nitro-benzenesulfonic acid 4-nitro-phenyl ester 
• 1303575-52-1 C₁₇H₁₆N₂O₇S 
• 1303577-14-1 methyl 1-hydroxy-5-(N-methyl-N-phenylsulfamoyl)-1H-indole-2-carboxylate 
• 1303572-27-1 1-hydroxy-5-(N-methyl-N-phenylsulfamoyl)-1H-indole-2-carboxylic acid 
• 1303573-81-0 N,3-dimethyl-4-nitro-N-phenylbenzenesulfonamide 
• 1321821-88-8 3,5-dimethyl-1-[(3-methyl-4-nitrophenyl)sulfonyl]piperidine 
• 1234481-10-7 XMD-12-3-1 

Relevant academic research and scientific papers

Use of compound binding to mSin3B that specifically binds to neuron restrictive silencer factor (NRSF)

The present invention identifies a compound which binds to the PAH1 domain of mSin3B that specifically binds to neural restrictive silencer factor NRSF, and uses the compound as a prophylactic and/or a therapeutic for diseases associated with abnormal expression of neural restrictive silencer factor NRSF/REST or abnormal expression of genes targeted by NRSF/REST, such as Huntington's disease, medulloblastoma and neuropathic pain. The present invention provides a pharmaceutical composition comprising a substance capable of binding to the PAH1 domain of mSin3B, e.g., a compound represented by the following formula (1), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof: wherein n represents 0 or 1; R1, R2, R3, R4 and R5 each independently represent a hydrogen atom, a hydrocarbon group or a functional group; Y represents a single bond, a carbonyl group, —CONH—, —NHCO— or a sulfonyl group; and Z represents a nitrogen-containing heterocyclic group which may have a substituent, an amino group which may have a hydrocarbon group or an aromatic hydrocarbon group, or a nitrogen and oxygen-containing heterocyclic group which may have a substituent.

Sulfonyl esters. 2. CS cleavage in some substitution reactions of nitrobenzensulfonates

An attempt to explore aromatic sulfonate esters as agents for the condensation of alcohols with mercaptans revealed an unusual process for sulfonate esters: CS bond rupture.Two mechanistic possibilities for CS bond rupture are explored: (i) radical anion intermediacy via singlet electron transfer and (ii) nucleophilic aromatic substitution.Both experiments and molecular orbital computations are presented to support the conclusion that nucleophilic aromatic substitutions are occuring.