1303609-24-6Relevant articles and documents
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
Zhao, Yujun,Liu, Liu,Sun, Wei,Lu, Jianfeng,McEachern, Donna,Li, Xiaoqin,Yu, Shanghai,Bernard, Denzil,Ochsenbein, Philippe,Ferey, Vincent,Carry, Jean-Christophe,Deschamps, Jeffrey R.,Sun, Duxin,Wang, Shaomeng
supporting information, p. 7223 - 7234 (2013/06/27)
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new