1303612-73-8

Basic information

• Product Name: (R,E)-2-(3-methyl-1-phenylbut-1-en-2-yl)-4-methylenetetrahydrofuran
• CAS NO: 1303612-73-8
• Molecular Weight: 228.334
• Mol File: 1303612-73-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,E)-2-(3-methyl-1-phenylbut-1-en-2-yl)-4-methylenetetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-2-(3-methyl-1-phenylbut-1-en-2-yl)-4-methylenetetrahydrofuran(1303612-73-8)
• EPA Substance Registry System: (R,E)-2-(3-methyl-1-phenylbut-1-en-2-yl)-4-methylenetetrahydrofuran(1303612-73-8)

Safety Data

• Hazardous Substances Data: 1303612-73-8(Hazardous Substances Data)

Upstream product

• 72047-94-0 [2-(acetoxymethyl)prop-2-enyl]trimethylsilane 
• 75101-96-1 α-isopropyl cinnamaldehyde 

Relevant articles and documents

Asymmetric synthesis of methylenetetrahydrofurans by palladium-catalyzed [3 + 2] cycloaddition of trimethylenemethane with aldehydes - A novel ligand design

The palladium-catalyzed [3 + 2] cycloaddition of trimethylenemethane (TMM) with aldehydes is a direct and efficient route to methylenetetrahydrofurans. Herein we describe the first asymmetric synthesis of methylenetetrahydrofurans utilizing a palladium-TMM complex in the presence of a novel phosphoramidite ligand possessing a stereogenic phosphorus. The method allows for the formation of chiral disubstituted tetrahydrofurans in good yields and enantioselectivities.