13037-56-4

Basic information

• Product Name: (5E)-5-benzylidene-3-phenyl-2-thioxo-1,3-thiazolidin-4-one
• Synonyms: (5E)-5-Benzylidene-3-phenyl-2-thioxo-1,3-thiazolidin-4-one; 4-thiazolidinone, 3-phenyl-5-(phenylmethylene)-2-thioxo-, (5E)-; Rhodanine, 5-benzylidene-3-phenyl
• CAS NO: 13037-56-4
• Molecular Formula: C₁₆H₁₁NOS₂
• Molecular Weight: 297.3946
• Mol File: 13037-56-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.3°C at 760 mmHg
• Flash Point: 223.1°C
• Density: 1.39g/cm³
• Vapor Pressure: 4E-08mmHg at 25°C
• Refractive Index: 1.749
• CAS DataBase Reference: (5E)-5-benzylidene-3-phenyl-2-thioxo-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5E)-5-benzylidene-3-phenyl-2-thioxo-1,3-thiazolidin-4-one(13037-56-4)
• EPA Substance Registry System: (5E)-5-benzylidene-3-phenyl-2-thioxo-1,3-thiazolidin-4-one(13037-56-4)

Safety Data

• Hazardous Substances Data: 13037-56-4(Hazardous Substances Data)

Upstream product

• 1457-46-1 3-phenylrhodanine 
• 100-52-7 benzaldehyde 
• 103-72-0 phenyl isothiocyanate 
• 36937-44-7 5-benzylidene-2-morpholino-1,3-thiazol-4(5H)-one 

Downstream Products

• 210990-43-5 (4-Fluoro-phenyl)-dithiocarbamic acid (4-oxo-3-phenyl-2-thioxo-thiazolidin-5-yl)-phenyl-methyl ester 
• 1426097-55-3 2-((5S,6R,10S)-4-oxo-3,10-diphenyl-2-thioxo-1-thia-3-azaspiro[4.5]dec-7-en-6-yl)acetaldehyde 
• 1397692-16-8 (6S,10S)-3,6,10-triphenyl-2-thioxo-1-thia-3-azaspiro[4.5]decane-4,8-dione 
• 500263-81-0 3-ethoxycarbonyl-1,6-diphenyl-8-phenylmethylene-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 491875-40-2 8-phenylmethylene-1,3,6-triphenyl-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 500263-89-8 1,6-diphenyl-3-phenylaminocarbonyl-8-phenylmethylene-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 780786-08-5 1-(4-nitrophenyl)-8-phenylmethylene-6-phenyl-3-(2-thienyl)-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 780786-09-6 3-(2-furyl)-1-(4-nitrophenyl)-8-phenylmethylene-6-phenyl-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 1370010-89-1 1,6-diphenyl-8-phenylmethylene-3-styryl-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 500263-85-4 3-acetyl-1,6-diphenyl-8-Phenylmethylene-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 500263-87-6 1,6-diphenyl-8-phenylmethylene-3-(2-thienoyl)-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 500263-83-2 3-benzoyl-1,6-diphenyl-8-phenylmethylene-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 
• 1370010-90-4 1,6-diphenyl-8-phenylmethylene-3-(2-naphthoyl)-4,9-dithia-1,2,6-triazaspiro[4,4]nonan-2-ene-7-one 

Relevant articles and documents

Rhodanine derivatives as inhibitors of JSP-1

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.

Alkynylation of heterocyclic compounds using hypervalent iodine reagent

The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.

A facile synthesis of new fungitoxic fluorine-containing thiazolo-1,3-dithiins, thiazines and oxathiins

Dithioesters 4a-c obtained by Michael-type addition of N-(p-fluorophenyl) dithiocarbamic acid 3 to 3-aryl-5-benzylidenerhodanines 2a-c undergo intramolecular chemoselective heterocyclizations with cone H2SO4, NaOH and CH3l to afford 3,7-diaryl-5-(arylimin