13037-56-4

Upstream product

• 100-52-7 benzaldehyde 
• 1457-46-1 3-phenylrhodanine 
• 36937-44-7 5-benzylidene-2-morpholino-1,3-thiazol-4(5H)-one 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 102452-04-0 5-benzhydryl-3-phenyl-2-thioxo-thiazolidin-4-one 
• 138696-25-0 5-Benzyliden-3-phenyl-4-oxothiazolidin-2-thion-S-oxid 
• 42518-27-4 5-Benzyliden-3-phenylthiazolidin-2,4-dion 
• 210990-49-1 4-(4-Fluoro-phenyl)-3,7-diphenyl-4,7-dihydro-3H-thiazolo[4,5-d][1,3]thiazine-2,5-dithione 
• 1426097-55-3 2-((5S,6R,10S)-4-oxo-3,10-diphenyl-2-thioxo-1-thia-3-azaspiro[4.5]dec-7-en-6-yl)acetaldehyde 
• 1397692-16-8 (6S,10S)-3,6,10-triphenyl-2-thioxo-1-thia-3-azaspiro[4.5]decane-4,8-dione 
• 210990-43-5 (4-Fluoro-phenyl)-dithiocarbamic acid (4-oxo-3-phenyl-2-thioxo-thiazolidin-5-yl)-phenyl-methyl ester 

Relevant academic research and scientific papers

Rhodanine derivatives as inhibitors of JSP-1

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.

Reactions of N,N-Disubstituted 5-arylmethylidene-2-aminothiazol-4(5H)-ones with CH acids

N,N-Disubstituted 5-arylmethylidene-2-aminothiazol-4(5H)-ones reacted with diethyl malonate, ethyl benzoylacetate, acetylacetone, or cyclopentadiene in refluxing toluene and in presence of powdered sodium to give the respective 5-arylmethylidene-2′-amino-

Alkynylation of heterocyclic compounds using hypervalent iodine reagent

The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.

A convenient synthesis of 3,5-diarylthieto[2,3-d]thiazole-2-thiones, and expansion of their thiete ring with carbon disulphide

3-Aryl-5-arylidenerhodanines 3a-f react with 0,0-diethyl hydrogen phosphorodithioate 4 to yield 3,5-diarylthieto[2,3-d]thiazole-2-thiones 6a-f in a one-pot procedure. The compounds 6a-f undergo expansion of their thiete ring by the reaction with carbon disulphide, catalysed by lithium iodide, to afford the corresponding 3,7-diarylthiazolo[4,5-d]-1,3-dithiin-2,5-dithiones 7a-f in high yields under mild conditions.

A facile synthesis of new fungitoxic fluorine-containing thiazolo-1,3-dithiins, thiazines and oxathiins

Dithioesters 4a-c obtained by Michael-type addition of N-(p-fluorophenyl) dithiocarbamic acid 3 to 3-aryl-5-benzylidenerhodanines 2a-c undergo intramolecular chemoselective heterocyclizations with cone H2SO4, NaOH and CH3l to afford 3,7-diaryl-5-(arylimin