1303953-89-0Relevant articles and documents
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1receptor antagonists and their biological evaluation
Koul, Summon,Ramdas, Vidya,Barawkar, Dinesh A.,Waman, Yogesh B.,Prasad, Neela,Madadi, Santosh Kumar,Shejul, Yogesh D.,Bonagiri, Rajesh,Basu, Sujay,Menon, Suraj,Reddy, Srinivasa B.,Chaturvedi, Sandhya,Chennamaneni, Srinivas Rao,Bedse, Gaurav,Thakare, Rhishikesh,Gundu, Jayasagar,Chaudhary, Sumit,De, Siddhartha,Meru, Ashwinkumar V.,Palle, Venkata,Chugh, Anita,Mookhtiar, Kasim A.
, p. 1963 - 1975 (2017/03/09)
Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and selective compounds were identified and evaluated for pharmacokinetic (PK) properties in Wistar rats. One of the compounds 14 with acceptable PK parameters was selected for testing in in vivo primary acute diuresis model. The compound demonstrated significant diuretic activity in this model.
SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF
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Page/Page column 74; 77, (2011/06/11)
The present invention provides substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating co
