1303963-32-7

Basic information

• Product Name: 8-[chloro(p-tolylsulfinyl)methyl]-8-[(4-fluorophenyl)ethynyl]-1,4-dioxaspiro[4.5]decane
• Synonyms: 8-[chloro(p-tolylsulfinyl)methyl]-8-[(4-fluorophenyl)ethynyl]-1,4-dioxaspiro[4.5]decane
• CAS NO: 1303963-32-7
• Molecular Weight: 446.97
• Mol File: 1303963-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-[chloro(p-tolylsulfinyl)methyl]-8-[(4-fluorophenyl)ethynyl]-1,4-dioxaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[chloro(p-tolylsulfinyl)methyl]-8-[(4-fluorophenyl)ethynyl]-1,4-dioxaspiro[4.5]decane(1303963-32-7)
• EPA Substance Registry System: 8-[chloro(p-tolylsulfinyl)methyl]-8-[(4-fluorophenyl)ethynyl]-1,4-dioxaspiro[4.5]decane(1303963-32-7)

Safety Data

• Hazardous Substances Data: 1303963-32-7(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 209391-72-0 8-[Chloro-(toluene-4-sulfinyl)-methylene]-1,4-dioxa-spiro[4.5]decane 

Downstream Products

• 1208244-99-8 8-[3-(4-fluorophenyl)prop-2-yn-1-ylidene]-1,4-dioxaspiro[4.5]decane 

Relevant articles and documents

Synthesis of conjugated enynes by assembly of three components, ketones, chloromethyl p-tolyl sulfoxide, and acetylenes, with the magnesium carbenoid 1,2-CC insertion as the key reaction

The reaction of 1-chlorovinyl p-tolyl sulfoxides, which were derived from ketones and chloromethyl p-tolyl sulfoxide, with lithium acetylides gave adducts in moderate to good yields. Treatment of the adducts with Grignard reagents resulted in the formation of magnesium carbenoids by the sulfoxide-magnesium exchange reaction. 1,2-Carbon-carbon insertion (1,2-CC insertion) reaction of the generated magnesium carbenoids took place to afford conjugated enynes in good to high yields. This procedure provides a good method for the synthesis of multi-substituted conjugated enynes.