1303996-67-9

Basic information

• Product Name: (R)-Valiolamine Voglibose
• Synonyms: (R)-Valiolamine Voglibose
• CAS NO: 1303996-67-9
• Molecular Formula: C17H34N2O11
• Molecular Weight: 442.45866
• Mol File: 1303996-67-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 749.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• PKA: 13.56±0.70(Predicted)
• CAS DataBase Reference: (R)-Valiolamine Voglibose(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Valiolamine Voglibose(1303996-67-9)
• EPA Substance Registry System: (R)-Valiolamine Voglibose(1303996-67-9)

Safety Data

• Hazardous Substances Data: 1303996-67-9(Hazardous Substances Data)

Usage

Uses

(R)-Valiolamine Voglibose is the main R-enantiomeric intermediate of Voglibose (V750000), an α-glucosidase inhibitor that works by delaying the digestion and absorption of carbohydrates, thereby inhib iting postprandial hyperglycemia and hyperinsulinemia.

Upstream product

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Relevant articles and documents

Preparation method of high-purity amino sugar drug impurity

The invention discloses a preparation method of a high-purity amino sugar drug impurity, the amino sugar drug impurity has a structure as shown in formula (I): weak acid is used for catalyzing valiolamine to react with 1, 3-dihydroxy acetone to prepare the amino sugar drug impurity, and the HPLC (high performance liquid chromatography) purity in a reaction product is greater than 20%. The method is high in yield, environment-friendly and suitable for industrial production of amino sugar drug impurities. The invention further discloses a method for purifying the amino sugar drug impurities from the reaction liquid, and the optimal HPLC purity of the purified amino sugar drug impurities is 98% or above.