130409-59-5

Usage

Type of compound

Propanoate ester

Derived from

Cyclohexenol and phenylmethyl

Common uses

a. Flavoring agent in the food industry
b. Fragrance in the perfume industry
c. Intermediate in the synthesis of other organic compounds

Physical state

Clear, colorless liquid

Aroma

Pleasant

Stability

Relatively stable under normal conditions

Safety precautions

a. Potential for skin and eye irritation
b. Handle with care to avoid contact

Upstream product

• 946-33-8 2-benzylcyclohexan-1-one 
• 123-62-6 propionic acid anhydride 
• 112211-72-0 methyl 1-benzyl-2-oxocyclohexanecarboxylate 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 
• 620-05-3 iodomethylbenzene 

Downstream Products

• 946-33-8 (S)-2-benzylcyclohexanone 
• 946-33-8 (R)-2-benzylcyclohexanone 

Relevant academic research and scientific papers

Enzyme-mediated enantioface-differentiating hydrolysis of α-substituted cycloalkanone enol esters

A new type of enzymatic hydrolysis, enantioface-differentiating hydrolysis of enol esters, is disclosed. As a result of screening, Pichia miso IAM 4682, a type of yeast, was selected as the best strain to perform the enantioselective hydrolysis of enol esters to give α-chiral ketones. For example, incubation of 1-acetoxy-2-methylcyclohexene (4a) with P. miso afforded (S)-2-methylcyclohexanone (5) in high optical yield. This enzymatic hydrolysis is applicable to various α-substituted cycloalkanone enol esters, and thereby chiral six-, eight-, ten-, and twelve-membered-ring ketones of 70-96% enantiomeric excess (ee) are easily prepared.