1304126-85-9

Upstream product

• 1247072-04-3 methyl 1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate 
• 1247072-06-5 methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 50820-65-0 indole-6-carboxylic acid methyl ester 

Downstream Products

• 875271-85-5 [2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid methyl ester 
• 1304126-86-0 methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate 
• 1304126-87-1 methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate 
• 1304126-88-2 methyl 2-(5-((1-(4-(1,3-dioxoisoindolin-2yl)butyl)-2-pheny-1H-indole)-6-carbonyl)-2-(3-phenyl)thiophen-3-yl)acetate 

Relevant academic research and scientific papers

Increasing synthetic efficiency via direct C-H functionalization: Formal synthesis of an inhibitor of botulinum neurotoxin

A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C-H functionalization reactions, formally activating three C-H bonds. The Royal Society of Chemistry 2011.