875271-85-5

Upstream product

• 1247072-04-3 methyl 1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate 
• 1247072-06-5 methyl 2-phenyl-1-[2-(trimethylsilyl)ethoxymethyl]-indole-6-carboxylate 
• 1304126-85-9 2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carboxylic acid 
• 1304126-86-0 methyl 5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-ylacetate 
• 1304126-87-1 methyl (2-phenyl-5-(2-phenyl-1-[2-(trimethylsilyl)-ethoxymethyl]-indole-6-carbonyl)thiophen-3-yl)acetate 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 62404-09-5 2-Phenyl-3-thienylacetic acid 
• 875271-83-3 [5-(4-iodo-3-nitro-benzoyl)-2-phenyl-thiophen-3-yl]-acetic acid methyl ester 
• 875271-79-7 (2-phenylthiophen-3-yl)acetic acid methyl ester 
• 875271-88-8 {5-[3-amino-4-(phenylethynyl)benzoyl]-2-phenylthiophene-3-yl}acetic acid methyl ester 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 875271-84-4 [5-(3-amino-4-iodo-benzoyl)-2-phenyl-thiophen-3-yl]-acetic acid methyl ester 
• 136343-83-4 (E)-4-Chloro-3-formyl-4-phenyl-but-3-enoic acid ethyl ester 
• 875271-86-6 (2-phenylthiophen-3-yl)acetic acid ethyl ester 

Downstream Products

• 875271-93-5 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid methyl ester 
• 1304126-88-2 methyl 2-(5-((1-(4-(1,3-dioxoisoindolin-2yl)butyl)-2-pheny-1H-indole)-6-carbonyl)-2-(3-phenyl)thiophen-3-yl)acetate 
• 1021171-88-9 (6-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-hexyl)-carbamic acid tert-butyl ester 
• 875271-95-7 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}-O-tritylhydroxy-acetamide 
• 875272-00-7 (4-{2-phenyl-6-[5-phenyl-4-(trityloxycarbamoyl-methyl)-thiophene-2-carbonyl]-indol-1-yl}-butyl)-carbamic acid tert-butyl ester 
• 1021171-86-7 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}-N-hydroxyacetamide 
• 917079-03-9 {4-[6-(4-hydrazinocarbonylmethyl-5-phenyl-thiophene-2-carbonyl)-2-phenyl-indol-1-yl]-butyl}-carbamic acid tert-butyl ester 
• 875271-89-9 2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide 
• 875271-92-4 2-{5-[1-(4-N-Boc-aminobutyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}-N-hydroxyacetamide 
• 875271-94-6 2-{5-[1-(5-N-Boc-aminopentyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid 
• 875271-91-3 [5-(1-{4-[(tert-butoxycarbonyl)amino]butyl}-2-phenyl-1H-indole-6-carbonyl)-2-phenylthiophene-3-yl]acetic acid 
• 875271-72-0 [2-Phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid 
• 875271-90-2 {5-[1-(4-N-boc-aminobutyl)-2-phenyl-1H-indol-6-carbonyl]-2-phenylthiophen-3-yl}acetic acid methyl ester 

Relevant academic research and scientific papers

Increasing synthetic efficiency via direct C-H functionalization: Formal synthesis of an inhibitor of botulinum neurotoxin

A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C-H functionalization reactions, formally activating three C-H bonds. The Royal Society of Chemistry 2011.

SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS

Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

Botulinum neurotoxin serotype A (BoNTA) is one of the most toxic substances known. Currently, there is no antidote to BoNTA. Small molecules identified from high-throughput screening reportedly inhibit the endopeptidase-the zinc-bound, catalytic domain of