13044-37-6Relevant articles and documents
Lipid nanoparticle formulations of non-viral capsid-free DNA vectors
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Paragraph 0403; 0408, (2020/09/26)
Provided herein are lipid nanoparticle formulations that comprise an ionizable lipid and non-viral, capsid-free DNA vectors with covalently-closed ends.
3 - (1 - Piperazine - 4 - yl uncle ding yangtang acid radical) propionic acid amphiphilic derivatives and use thereof (by machine translation)
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Paragraph 0052; 0070; 0078; 0079; 0080, (2018/07/30)
The invention relates to an amphiphilic derivative of 3-(1-tert-butoxycarbonylpiperazin-4-yl)propionic acid, and a use thereof, and also relates to a liposome prepared from the amphiphilic derivative. The use is the use of the liposome as a drug carrier delivery system. The liposome prepared from the amphiphilic derivative can be compounded with gene drug siRNA to form a compound with small particle size and uniform particle size distribution. The amphiphilic derivative is electrically neutral in environment with the pH value of 7.4, increases the in vivo stability of the lipid compound and reduces cytotoxicity caused by too many positive charges. The liposome can specifically inhibit gene expression in human non-small cell lung cancer H1299-Pg13 cells in vitro, and can specifically transship fluorescence gene drugs into normal mouse liver cells in vivo.
Di-aliphatic substituted pegylated lipids
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Page/Page column 103, (2017/08/08)
The disclosure relates to di-aliphatic substituted PEGylated lipids and to methods of their preparation. The disclosure also relates to lipid conjugates containing di-aliphatic substituted PEGylated lipids, and to the use of di-aliphatic substituted PEGylated-lipid conjugates in drug delivery.
