51154-39-3

Basic information

• Product Name: 9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)-
• Synonyms: (9Z,12Z)-Octadeca-9,12-dienyl methanesulfonate;1-Methylsulfonyloxyoctadeca-9Z,12Z-diene;cis,cis-9,12-Octadecadienyl methanesulfonate;Linoleyl methanesulfonate;9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)-
• CAS NO: 51154-39-3
• Molecular Formula: C₁₉H₃₆O₃S
• Molecular Weight: 344.55234
• Mol File: 51154-39-3.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)-(51154-39-3)
• EPA Substance Registry System: 9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)-(51154-39-3)

Safety Data

• Hazardous Substances Data: 51154-39-3(Hazardous Substances Data)

Usage

General Description

9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)- is a chemical compound that contains a long chain of 18 carbon atoms with two double bonds at the 9th and 12th positions. It is typically found as a methanesulfonate salt, which is a derivative of methanesulfonic acid. 9,12-Octadecadien-1-ol, methanesulfonate, (9Z,12Z)- is commonly used in organic synthesis and as a precursor for the production of various chemicals and materials. It has potential applications in the pharmaceutical and cosmetic industries, as well as in the manufacture of surfactants and emulsifiers. The (9Z,12Z)- designation refers to the configuration of the double bonds in the compound, indicating that they are in the cis configuration.

Upstream product

• 60-33-3 linoleic acid 
• 506-43-4 Linoleyl alcohol 
• 7143-01-3 Methanesulfonic anhydride 
• 29204-30-6 methyl (10Z,13Z)-nonadeca-10,13-dienoate 
• 124-63-0 methanesulfonyl chloride 
• 112-63-0 Methyl linoleate 

Downstream Products

• 1003579-68-7 dilinoleyloxybenzaldehyde 
• 4102-60-7 (Z,Z)-octadeca-9,12-dienyl bromide 
• 1346224-34-7 (3S,4S)-1-benzyl-3,4-bis((9Z,12Z)-octadec-9,12-dienyloxy)pyrrolidine 
• 17367-08-7 2-[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]ethanol 

Relevant articles and documents

Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities

Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l–5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKGs (5a–5k, 5o). Their structures were established using 1H and 13C APT NMR with 2D-NMR, ESI-MS or HRESI-MS and optical rotation data, and they were tested for their antibacterial and antibiofilm activities. AKGs 5a–5m and 5o showed activity against five clinical isolates and P. aeruginosa ATCC 15442, with MIC values in the range of 15–125 μg/mL. In addition, at half of the MIC, most of the AKGs reduced S. aureus biofilm formation in the range of 23%–99% and P. aeruginosa ATCC 15442 biofilm formation in the range of 14%–64%. The antibiofilm activity of the AKGs assessed in this work had not previously been studied.

COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS

The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

3 - ((2 - (Dimethylamino) ethyl) (methyl) amino) propionic acid amphiphilic derivatives and use thereof

The invention relates to an amphiphilic derivative of 3-((2-dimethylamino)ethyl(methyl)amino)propionic acid, and a use thereof, and also relates to a liposome prepared from the above amphiphilic compound. The use is the use of the liposome as a drug carrier delivery system. The liposome prepared from the amphiphilic compound has many positive charges in acidic environment, and can be well compounded with gene drug siRNA to form a compound with small particle size and uniform particle size distribution. The amphiphilic compound is electrically neutral in environment with the pH value of 7.4, increases the in vivo stability of the lipid compound and reduces cytotoxicity caused by too many positive charges. The liposome can specifically inhibit gene expression in human non-small cell lung cancer H1299-Pg13 cells in vitro, and can specifically transship fluorescence gene drugs into normal mouse liver cells in vivo.