130441-68-8

Usage

Uses

Used in Organic Synthesis:
(2-(prop-2-yn-1-yloxy)phenyl)methanol is utilized as a building block in organic synthesis for the preparation of a variety of organic compounds and pharmaceuticals. Its versatile structure allows for the creation of diverse molecules, contributing to the advancement of chemical research and development.
Used in Fragrance and Flavor Production:
(2-(prop-2-yn-1-yloxy)phenyl)methanol is also used as an intermediate in the production of fragrances and flavors, capitalizing on its chemical properties to create aromatic and taste-enhancing agents for various consumer products.
Used in Chemical Intermediates:
(2-(prop-2-yn-1-yloxy)phenyl)methanol serves as an important intermediate in the chemical industry, playing a crucial role in the synthesis of other complex molecules and contributing to the development of new materials and products.
Used in Research and Industrial Settings:
Due to its potential applications and reactivity, (2-(prop-2-yn-1-yloxy)phenyl)methanol is frequently employed in both research and industrial settings for a wide range of synthetic purposes, further expanding its utility and significance in the field of chemistry.

Upstream product

• 90-01-7 salicylic alcohol 
• 106-96-7 propargyl bromide 
• 89-95-2 2-methyl-benzyl alcohol 
• 29978-83-4 o-propargyloxybenzaldehyde 

Downstream Products

• 29978-83-4 o-propargyloxybenzaldehyde 
• 1321627-76-2 C₁₆H₁₃NO₄ 
• 149244-09-7 1-prop-2-ynyloxy-2-azidomethylbenzene 
• 886969-05-7 (3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-6-(2-prop-2-ynyloxy-benzyloxy)-tetrahydro-furo[2,3-d][1,3]dioxole 
• 886969-01-3 1-bromomethyl-2-prop-2-ynyloxy-benzene 
• 886969-08-0 ((3aR,5R,6S,6aR)-5-Azidomethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy)-acetic acid 2-prop-2-ynyloxy-benzyl ester 
• 153034-38-9 1-(chloromethyl)-2-(prop-2-yn-1-yloxy)benzene 

Relevant academic research and scientific papers

Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles

To explore anticancer and antioxidant agents with improved potency, we synthesized a series of amide linked 1,4-disubstituted 1,2,3-triazoles through click chemistry approach. The structure of synthesized triazoles were characterized by- FTIR, 1H NMR, 13C NMR spectroscopy and HRMS. All the synthesized compounds were screened for their anticancer activity against four different cell lines- PC3 (prostate cancer), A549 (lung cancer), MIAPACA (liver cancer), Fr2 (Breast epithelial), reflecting compounds 7e and 7f to possess good activity. The antioxidant activity was evaluated by using stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and compound 7d showed promising activity having IC50 value 1.61 μg/ml. Molecular docking studies of compounds 7e and 7f was carried out in active site of human epidermal growth factor receptor 2 revealed high binding affinities and within toxicity limits. The experimental results were in good agreement with docking studies. In-silico ADME studies of synthesized compounds also have good dispositional profile and are patient compliant, may be potential future candidates for anticancer treatment.

Intramolecular copper(I)-catalyzed 1,3-dipolar cycloaddition of azido-alkynes: Synthesis of triazolo-benzoxazepine derivatives and their biological evaluation

Synthesis of a series of [1,2,3] triazolo [5,1-c] [1,4]benzoxazepine derivatives have been accomplished by the intramolecular Cu(I)-catalyzed cycloaddition of azido-alkynes derived from salicylaldehyde. The biological profile of these heterocyclic structu

Cu(I)-Catalyzed cycloaddition of constrained azido-alkynes: Access to 12- to 17-membered monomeric triazolophanes incorporating furanoside rings

A strained monomeric 12-membered triazolophane was formed by the Cu(I)-catalyzed intramolecular cycloaddition of an azide to an alkyne having a constrained tether incorporating an aromatic ring and a furanoside ring. Similar cycloadditions of azido-alkyne

Steric acceleration of intramolecular cycloaddition reactions

Use of conformational constraints, induced by different ortho-substituents in 1-allyloxy-2-(substituted)methylbenzenes, where the substituent is a 1,3-dipole such as the azide or 3-oxidopyridinium group, can be employed to accelerate the 1,3-dipolar cycloaddition reaction. In this manner cycloadditions that otherwise do not proceed can be forced to react.

N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents

This invention relates to N-hydroxy-N-[3-(2-substituted phenyl)prop-2-enyl]ureas and thioureas, formulations containing those compounds, and methods of using such compounds as 5-lipoxygenase inhibiting agents.