130446-89-8

Basic information

• Product Name: Z-L-Ala 2-chloroethyl ester
• Synonyms: Z-L-Ala 2-chloroethyl ester
• CAS NO: 130446-89-8
• Molecular Weight: 285.727
• Mol File: 130446-89-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Z-L-Ala 2-chloroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Ala 2-chloroethyl ester(130446-89-8)
• EPA Substance Registry System: Z-L-Ala 2-chloroethyl ester(130446-89-8)

Safety Data

• Hazardous Substances Data: 130446-89-8(Hazardous Substances Data)

Upstream product

• 1142-20-7 N-Cbz-Ala 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 50444-54-7 benzyl (S)-1-((S)-1-amino-1-oxopropan-2-ylamino)-1-oxopropan-2-ylcarbamate 
• 130446-83-2 (S)-2-Benzyloxycarbonylamino-propionic acid (1S,6S,7R,8R,8aS)-6,7,8-trihydroxy-octahydro-indolizin-1-yl ester 
• 23458-22-2 Z-(S)-Ala-(S)-Pro-OBzl 
• 1142-20-7 N-Cbz-Ala 
• 18323-56-3 Z-(S)-Ala-(S)-Leu-NH₂ 

Relevant articles and documents

Broadening of the substrate tolerance of α-chymotrypsin by using the carbamoylmethyl ester as an acyl donor in kinetically controlled peptide synthesis

In the kinetically controlled approach of peptide synthesis mediated by α-chymotrypsin, the broadening of the protease's substrate tolerance is achieved by switching the acyl donor from the conventional methyl ester to the carbamoylmethyl ester. Thus, as a typical example, the extremely low coupling efficiency obtained by employing the methyl ester of an inherently poor amino acid substrate, Ala, is significantly improved by the use of this particular ester. Its ameliorating effect is observed also in the couplings of other amino acid residues such as Gly and Ser as carboxy components.