130447-88-0

Basic information

• Product Name: Benzenepropanol, 3-methoxy-4-(2-propenyloxy)-
• CAS NO: 130447-88-0
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol File: 130447-88-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, 3-methoxy-4-(2-propenyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, 3-methoxy-4-(2-propenyloxy)-(130447-88-0)
• EPA Substance Registry System: Benzenepropanol, 3-methoxy-4-(2-propenyloxy)-(130447-88-0)

Safety Data

• Hazardous Substances Data: 130447-88-0(Hazardous Substances Data)

Upstream product

• 2305-13-7 3-Guaiacylpropanol 
• 106-95-6 allyl bromide 
• 97-53-0 4-allylguaiacol 

Downstream Products

• 6245-54-1 2-hydroxy-5-(3-hydroxy-propyl)-3-methoxy-benzaldehyde 
• 125874-72-8 3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol 
• 875213-63-1 2,2-dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-{5-[3-(2,2-dimethyl-propionyloxy)-propyl]-7-methoxy-3-vinyl-2,3-dihydro-benzofuran-2-yl}-phenyl ester 
• 920518-80-5 2,2-dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-{5-[3-(2,2-dimethyl-propionyloxy)-propyl]-3-formyl-7-methoxy-2,3-dihydro-benzofuran-2-yl}-phenyl ester 
• 920518-59-8 2,2-dimethyl-propionic acid 3-{2-[4-(2,2-dimethyl-propionyloxy)-3-methoxy-phenyl]-3-formyl-7-methoxy-2,3-dihydro-benzofuran-5-yl}-propyl ester 
• 875213-62-0 2,2-dimethyl-propionic acid 3-{2-[4-(2,2-dimethyl-propionyloxy)-3-methoxy-phenyl]-7-methoxy-3-vinyl-2,3-dihydro-benzofuran-5-yl}-propyl ester 
• 875213-61-9 2,2-Dimethyl-propionic acid 3-[4-(allyl-dimethyl-silanyloxy)-3-methoxy-5-((E)-propenyl)-phenyl]-propyl ester 
• 875213-64-2 2,2-Dimethyl-propionic acid 3-[4-hydroxy-3-methoxy-5-((E)-propenyl)-phenyl]-propyl ester 
• 919764-09-3 [2-methoxy-6-(methoxycarbonylmethyl)-4-(3-pivaloyloxypropyl)phenyl][3,4-di(pivaloyloxy)benzyl] ether 
• 919764-06-0 [2-methoxy-4-(3-pivaloyloxypropyl)-6-(2-propenyl)phenyl][3,4-di(pivaloyloxy)benzyl] ether 

Relevant articles and documents

A diastereoselective route to trans-2-aryl-2,3-dihydrobenzofurans through sequential cross-metathesis/isomerization/allylboration reactions: Synthesis of bioactive neolignans

A new highly diastereoselective synthetic route to trans-2,3-dihydrobenzofuran systems, in particular those bearing an aryl substituent at the C2 position, is described. The cornerstone of our strategy is the implementation of a cross-metathesis/isomerization/allylboration sequence starting from 2-allyl-substituted phenols and aldehydes. After an intramolecular Mitsunobu cyclization step, the anti-homoallylic alcohols allow the synthesis of the desired skeleton in a stereoselective fashion. As an illustration, we used this strategy for the preparation of the dihydrodehydrodiconiferyl alcohol (1a), a natural dihydrobenzofuran neolignan, as well as for a formal synthesis of its O-demethylated derivative 1b. An enantioselective version of this approach employing a chiral phosphoric acid in the allylboration step is also studied.