130450-11-2

Upstream product

• 130450-08-7 2-Benzyl-2-(2,2-dimethoxy-ethyl)-malonic acid dimethyl ester 
• 51534-81-7 dimethyl 2-(2,2-dimethoxyethyl)-1,3-propanedioate 
• 29805-49-0 methyl 2-allyl-3-phenylpropionate 
• 149-73-5 trimethyl orthoformate 
• 124-41-4 sodium methylate 

Downstream Products

• 691876-02-5 2-benzyl-4,4-dimethoxy-butyric acid 
• 130450-13-4 methyl 2-benzyl-4-oxobutanoate 

Relevant academic research and scientific papers

Synthesis of functionalized γ-lactone via Sakurai exo -cyclization/rearrangement of 3,3-bis(silyl) enol ester with a tethered acetal

An efficient synthesis of functionalized γ-lactones has been developed involving Sakurai exo-cyclization/rearrangement of 3,3-bis(silyl) enol esters with a tethered acetal. While the steric and electronic effects of geminal bis(silane) favor the desired Sakurai pathway, the methoxy species formed in the deprotection step also facilitates both cyclization and rearrangement. The synthetic value of this approach has been demonstrated by efficiently transforming the E-vinylsilane into enyne and the γ-lactone moiety into multisubstituted THF.

GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

Facile Synthesis of Some Substituted Methyl 3-Formylpropanoates

Variously substituted methyl 3-formylpropanoates are prepared in high yields by the reaction of methyl 4,4-dimethoxybutanoates with titanium tetrachloride.