130459-40-4Relevant academic research and scientific papers
Synthetic studies on the polyene macrolide antibiotics. Development of syn- and anti-1,3-diol subunits and assembly of the polyacetate region of amphotericin B
McGarvey,Mathys,Wilson,Overly,Buonora,Spoors
, p. 7778 - 7790 (2007/10/03)
The synthesis of syn- and anti-1,3-diol subunits from thiol ester oxazoline 4 has been described. The key features of these synthetic sequences include the stereodivergent allylation of an asymmetric β-amino aldehyde (7) and the stereospecific transformat
Studies toward the application of oxazoline-epoxide equivalency in 1,3-asymmetric induction
Overly,Williams,McGarvey
, p. 4573 - 4576 (2007/10/02)
Synthetically versatile epoxy alcohols have been prepared from a common intermediate, chiral aldehyde, through a sequence involving diastereoselective allylation followed by stereospecific transformation of the oxazoline to an epoxide.
