171524-11-1Relevant articles and documents
A convergent preparation of the C1-C13 fragment of amphotericin B from a single chiral precursor
Bonini, Carlo,Chiummiento, Lucia,Martuscelli, Angela,Viggiani, Licia
, p. 2177 - 2179 (2007/10/03)
A short, highly efficient, stereoconvergent synthesis of the polyolic chain, C1-C13, of the macrolide antibiotic amphotericin B is described. The key features of the synthesis are the use of a single chiral precursor for the establishment of the stereogenic centres in a short synthetic sequence, and the final alkyl lithium addition to the appropriate aldehyde, which showed high diastereoselectivity for the correct stereochemistry at the fifth stereogenic centre.
Synthetic studies on the polyene macrolide antibiotics. Development of syn- and anti-1,3-diol subunits and assembly of the polyacetate region of amphotericin B
McGarvey,Mathys,Wilson,Overly,Buonora,Spoors
, p. 7778 - 7790 (2007/10/03)
The synthesis of syn- and anti-1,3-diol subunits from thiol ester oxazoline 4 has been described. The key features of these synthetic sequences include the stereodivergent allylation of an asymmetric β-amino aldehyde (7) and the stereospecific transformat