130472-43-4

Upstream product

• 22900-10-3 (4R,5S)-tetrahydro-2H-pyran-2,4,5-triol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 22900-10-3 2-deoxy-D-ribose 

Downstream Products

• 130472-46-7 3-O-<(tert-butyl)dimethylsilyl>-2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-α/β-D-ribofuranose 
• 130472-48-9 1,3-bis-O-<(tert-butyl)dimethylsilyl>-2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-α/β-D-ribofuranose 
• 130472-44-5 1-O-<(tert-butyl)dimethylsilyl>-2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-α-D-ribofuranose 
• 130472-45-6 1-O-<(tert-butyl)dimethylsilyl>-2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranose 
• 197784-39-7 {(2S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-thioacetic acid S-benzyl ester 
• 197784-37-5 ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]acetate 
• 197784-38-6 ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]acetate 
• 130472-50-3 1-O-<(tert-butyl)dimethylsilyl>-3-O-<(2-cyanoethoxy)(N,N-diisopropylamino)phosphino>-2-deoxy-α-D-ribofuranose 

Relevant academic research and scientific papers

C-glycoside phosphoramidite building block for versatile functionalization of oligodeoxyribonucleotides

A chiral non-nucleosidic phosphoramidite building block containing a thioester function in its structure, 4, is synthesized in six steps starting from '2-deoxy-D-ribose'. It is used in the machine-assisted oligonucleotide synthesis in a conventional manner. Upon completion of the oligonucleotide chain assembly the thioester bond is cleaved with various nucleophiles (hydroxide ion, propane-1,3-diamine, cystamine, histamine), resulting in oligonucleotide conjugates with a tether group in the middle of the oligonucleotide chain.

62. A Method for Preparing Oligodeoxynucleotides Containing an Apurinic Site

In three steps, 2-deoxy-D-ribose has been converted into a phosphoramidite building block bearing a (t-Bu)Me2Si protecting group at the OH function of the anomeric centre of the furanose ring.This building block was subsequently incroporated into DNA olig